DegronMD

Uniprot ID: Q8NFJ9

Source protein: Bardet-Biedl syndrome 1 protein

Source gene: BBS1

Class: LIG_APCC_ABBAyCdc20_2

Location: 430:436

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.75

ASA_SCORE: 75.7857

COIL: 0.3831

CONS_SCORE: 0.6177

DSS_SCORE: 0.3849

HELIX: 0.561

FCONS_SCORE: 1.2327

RIG_SCORE: 0.8344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q421H	TCGA-AD-6964	COAD	TCGA	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q421H	DO8360	COAD	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.N426I	TCGA-AP-A051	UCEC	TCGA	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.N426I	DO42673	UCEC	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R440Q	TCGA-AZ-6601	COAD	TCGA	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R440Q	DO8119	COAD	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.M423I	TCGA-GR-A4D4	DLBC	TCGA	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.M423I	DO219907	DLBC	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P443L	DO5535	BRCA	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V442L	DO229025	LICA	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.V442L	DO229045	LICA	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.N426S	DO35270	PACA	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.K430N	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K430N	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.6918
p.P434L	HDQ-P1	breast	COSMIC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.7582
p.R435L	SK-GT-2	stomach	COSMIC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFJ9	Bardet-Biedl syndrome 1 protein	LIG_APCC_ABBAyCdc20_2	430:436	KTRLYVD	APC,CDC20,FZR1	0.75	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons