DegronMD

Uniprot ID: Q9Y4H2

Source protein: Insulin receptor substrate 2

Source gene: IRS2

Class: DEG_SPOP_SBC_1

Location: 942:946

E3 ligase: SPOP

DEGRON score: 0.9702

ASA_SCORE: 71.14

COIL: 0.7668

CONS_SCORE: 0.3686

DSS_SCORE: 0.4757

HELIX: 0.2126

FCONS_SCORE: 1.0815

RIG_SCORE: 0.6335

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A942T	DO222973	BTCA	ICGC	AASSS	DEG_SPOP_SBC_1	0.7139
p.S941L	ACH-000552	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	0.3056
p.A940S	DO222760	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	0.2778
p.A940V	ACH-000999	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	0.2778
p.A951T	DO233935	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	0.1944
p.A951T	SIDM01608	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	0.1944
p.A951T	ACH-000990	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	0.1944
p.A935V	DO12034	GBM	ICGC	AASSS	DEG_SPOP_SBC_1	0.1389
p.P934A	ACH-000730	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 9 of 9 entries

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Drug responses associated with IRS2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AASSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C2	182 kDa tankyrase-1-binding protein	DEG_SPOP_SBC_1	1461:1465	AASSS	SPOP	0.6113	More...
P61927	60S ribosomal protein L37	DEG_SPOP_SBC_1	92:96	AASSS	SPOP	0.9084	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	912:916	AASSS	SPOP	0.9916	More...
Q96DE5	Anaphase-promoting complex subunit 16	DEG_SPOP_SBC_1	2:6	AASSS	SPOP	0.8429	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	430:434	AASSS	SPOP	0.9407	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	1084:1088	AASSS	SPOP	0.9765	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	384:388	AASSS	SPOP	0.991	More...
Q9H329	Band 4.1-like protein 4B	DEG_SPOP_SBC_1	44:48	AASSS	SPOP	0.8189	More...
Q8NFJ9	Bardet-Biedl syndrome 1 protein	DEG_SPOP_SBC_1	3:7	AASSS	SPOP	0.8652	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	96:100	AASSS	SPOP	0.9824	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	125:129	AASSS	SPOP	0.9934	More...
P22004	Bone morphogenetic protein 6	DEG_SPOP_SBC_1	165:169	AASSS	SPOP	0.8116	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	679:683	AASSS	SPOP	0.9948	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	659:663	AASSS	SPOP	0.6805	More...
O60583	Cyclin-T2	DEG_SPOP_SBC_1	472:476	AASSS	SPOP	0.9676	More...
P20585	DNA mismatch repair protein Msh3	DEG_SPOP_SBC_1	12:16	AASSS	SPOP	0.986	More...
Q01831	DNA repair protein complementing XP-C cells	DEG_SPOP_SBC_1	499:503	AASSS	SPOP	0.9944	More...
Q9H1R2	Dual specificity protein phosphatase 15	DEG_SPOP_SBC_1	288:292	AASSS	SPOP	0.9533	More...
Q03001	Dystonin	DEG_SPOP_SBC_1	1138:1142	AASSS	SPOP	0.7435	More...
Q09019	Dystrophia myotonica WD repeat-containing protein	DEG_SPOP_SBC_1	472:476	AASSS	SPOP	0.541	More...
Q9UHC7	E3 ubiquitin-protein ligase makorin-1	DEG_SPOP_SBC_1	129:133	AASSS	SPOP	0.9977	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_SPOP_SBC_1	452:456	AASSS	SPOP	0.9985	More...
Q99961	Endophilin-A2	DEG_SPOP_SBC_1	284:288	AASSS	SPOP	0.9979	More...
Q9UF56	F-box/LRR-repeat protein 17	DEG_SPOP_SBC_1	93:97	AASSS	SPOP	0.5855	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	961:965	AASSS	SPOP	0.9852	More...

Showing 1 to 25 of 87 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASSS

Degron related mutations and impact score

Drug responses associated with IRS2 mutations

All proteins holding degron of AASSS