DegronMD - P22004(BMP6)

GO - Biological processes (BP): BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cellular iron ion homeostasis [GO:0006879]; cellular response to BMP stimulus [GO:0071773]; cellular response to iron ion [GO:0071281]; cellular response to mechanical stimulus [GO:0071260]; endochondral ossification [GO:0001958]; eye development [GO:0001654]; immune response [GO:0006955]; inflammatory response [GO:0006954]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; multicellular organismal iron ion homeostasis [GO:0060586]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular permeability [GO:0043117]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to magnesium ion [GO:0032026]; response to retinoic acid [GO:0032526]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; type B pancreatic cell development [GO:0003323] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P246L	TCGA-2Y-A9HA	LIHC	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.P246L	DO219539	LIHC	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.P246T	TCGA-A5-A0G2	UCEC	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.P246T	DO41235	UCEC	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.V250M	TCGA-AB-2904	LAML	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1667
p.V250M	DO21649	LAML	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1667
p.G265E	TCGA-CH-5764	PRAD	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2222
p.G265E	DO36346	PRAD	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2222
p.G265E	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2222
p.G265E	ACH-000823	Esophageal Cancer	CCLE	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2222
p.G265E	KYSE-140	oesophagus	COSMIC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2222
p.P246S	TCGA-DA-A3F5	SKCM	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.P246S	TCGA-ER-A193	SKCM	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.P246S	DO37435	SKCM	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.P246S	DO47368	SKCM	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.0556
p.R257H	TCGA-DI-A1BU	UCEC	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.7133
p.R257H	DO233641	GACA	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.7133
p.R257H	DO42023	UCEC	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.7133
p.R257H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.7133
p.R257H	SIDM01689	B-Lymphoblastic Leukemia	GDSC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.7133
p.K268N	TCGA-EO-A22X	UCEC	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation substituting flanking lysine	0.25
p.K268N	DO43907	UCEC	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation substituting flanking lysine	0.25
p.G155R	TCGA-ER-A198	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.G155R	DO47563	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.E249K	TCGA-FS-A4FC	SKCM	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1389
p.E249K	DO37762	SKCM	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1389
p.E249D	TCGA-QC-A7B5	SARC	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1389
p.E249D	DO220239	SARC	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1389
p.E249D	SIDM01121	Small Cell Lung Carcinoma	GDSC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1389
p.E249D	ACH-000358	Lung Cancer	CCLE	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1389
p.E249D	NCI-H69	lung	COSMIC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1389
p.F256L	TCGA-QK-AA3J	HNSC	TCGA	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.587
p.F256L	DO52101	HNSC	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.587
p.P58L	DO227976	COCA	ICGC	PQSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2778
p.S167N	DO234230	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7069
p.S167N	ACH-000985	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7069
p.P174L	DO234250	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.P174L	SIDM02039	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.Q173K	DO233189	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.L67M	DO233088	GACA	ICGC	PQSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.25
p.A179V	DO233259	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P57S	DO233764	GACA	ICGC	PQSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.25
p.P174S	DO46396	OV	ICGC	AASSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.V263A	DO232224	PBCA	ICGC	FRIYKD	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2778
p.P56L	ACH-000785	Lung Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2222

Kaplan plot for BMP6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMP6

UniProt ID: P22004

Entrez ID: 654

Protein name: Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMP6 in