DegronMD

Uniprot ID: P22004

Source protein: Bone morphogenetic protein 6

Source gene: BMP6

Class: LIG_APCC_ABBA_1

Location: 256:261

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5946

ASA_SCORE: 29.3

COIL: 0.1313

CONS_SCORE: 0.5758

DSS_SCORE: 0.0689

HELIX: 0.0057

FCONS_SCORE: 1.3044

RIG_SCORE: 0.9581

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P246L	TCGA-2Y-A9HA	LIHC	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.0556
p.P246L	DO219539	LIHC	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.0556
p.P246T	TCGA-A5-A0G2	UCEC	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.0556
p.P246T	DO41235	UCEC	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.0556
p.V250M	TCGA-AB-2904	LAML	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.1667
p.V250M	DO21649	LAML	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.1667
p.G265E	TCGA-CH-5764	PRAD	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.2222
p.G265E	DO36346	PRAD	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.2222
p.G265E	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	FRIYKD	LIG_APCC_ABBA_1	0.2222
p.G265E	ACH-000823	Esophageal Cancer	CCLE	FRIYKD	LIG_APCC_ABBA_1	0.2222
p.G265E	KYSE-140	oesophagus	COSMIC	FRIYKD	LIG_APCC_ABBA_1	0.2222
p.P246S	TCGA-DA-A3F5	SKCM	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.0556
p.P246S	TCGA-ER-A193	SKCM	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.0556
p.P246S	DO37435	SKCM	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.0556
p.P246S	DO47368	SKCM	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.0556
p.R257H	TCGA-DI-A1BU	UCEC	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.7133
p.R257H	DO233641	GACA	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.7133
p.R257H	DO42023	UCEC	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.7133
p.R257H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	FRIYKD	LIG_APCC_ABBA_1	0.7133
p.R257H	SIDM01689	B-Lymphoblastic Leukemia	GDSC	FRIYKD	LIG_APCC_ABBA_1	0.7133
p.K268N	TCGA-EO-A22X	UCEC	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.25
p.K268N	DO43907	UCEC	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.25
p.E249K	TCGA-FS-A4FC	SKCM	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.1389
p.E249K	DO37762	SKCM	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.1389
p.E249D	TCGA-QC-A7B5	SARC	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.1389
p.E249D	DO220239	SARC	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.1389
p.E249D	SIDM01121	Small Cell Lung Carcinoma	GDSC	FRIYKD	LIG_APCC_ABBA_1	0.1389
p.E249D	ACH-000358	Lung Cancer	CCLE	FRIYKD	LIG_APCC_ABBA_1	0.1389
p.E249D	NCI-H69	lung	COSMIC	FRIYKD	LIG_APCC_ABBA_1	0.1389
p.F256L	TCGA-QK-AA3J	HNSC	TCGA	FRIYKD	LIG_APCC_ABBA_1	0.587
p.F256L	DO52101	HNSC	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.587
p.V263A	DO232224	PBCA	ICGC	FRIYKD	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRIYKD

Degron related mutations and impact score

Drug responses associated with BMP6 mutations

All proteins holding degron of FRIYKD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22004	Bone morphogenetic protein 6	LIG_APCC_ABBA_1	256:261	FRIYKD	APC,CDC20,FZR1	0.5946	More...