DegronMD - Q09019(DMWD)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P463T	TCGA-AA-A01R	COAD	TCGA	LPGTPGTT	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.5919
p.P463T	DO7934	COAD	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.5919
p.A473T	TCGA-F1-6177	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.6028
p.A473T	DO38727	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.6028
p.G84V	DO233680	GACA	ICGC	VRLSLVRLG	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.0556
p.R458S	DO233732	GACA	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.2222
p.S106R	DO228938	LICA	ICGC	VRLSLVRLG	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.2222
p.P470T	DO228974	LICA	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.3056
p.P470T	DO228974	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.R460C	DO228978	LICA	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.2778
p.S476W	DO50936	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7874
p.S476L	DO220886	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7667
p.H453P	DO229201	THCA	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.0833
p.S97G	DO229240	THCA	ICGC	VRLSLVRLG	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.5882
p.L96F	DO229250	THCA	ICGC	VRLSLVRLG	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.587
p.G482D	DO229088	THCA	ICGC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.P471S	SIDM01117	Small Cell Lung Carcinoma	GDSC	LPGTPGTT	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.2778
p.P471S	SIDM01117	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.3056
p.P471S	SIDM00210	Ovarian Carcinoma	GDSC	LPGTPGTT	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.2778
p.P471S	SIDM00210	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.3056
p.G102W	SIDM00927	Small Cell Lung Carcinoma	GDSC	VRLSLVRLG	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.6714
p.G102W	ACH-000871	Lung Cancer	CCLE	VRLSLVRLG	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.6714
p.P452S	ACH-000889	Myeloma	CCLE	LPGTPGTT	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMWD

UniProt ID: Q09019

Entrez ID: 1762

Protein name: Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMWD in