DegronMD

Uniprot ID: Q09019

Source protein: Dystrophia myotonica WD repeat-containing protein

Source gene: DMWD

Class: DEG_SCF_FBW7_1

Location: 462:469

E3 ligase: FBXW7

DEGRON score: 0.9419

ASA_SCORE: 53.2875

COIL: 0.868

CONS_SCORE: 0.3974

DSS_SCORE: 0.7647

HELIX: 0.0134

FCONS_SCORE: 0.9536

RIG_SCORE: 0.5501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P463T	TCGA-AA-A01R	COAD	TCGA	LPGTPGTT	DEG_SCF_FBW7_1	0.5919
p.P463T	DO7934	COAD	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	0.5919
p.R458S	DO233732	GACA	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	0.2222
p.P470T	DO228974	LICA	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	0.3056
p.R460C	DO228978	LICA	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	0.2778
p.H453P	DO229201	THCA	ICGC	LPGTPGTT	DEG_SCF_FBW7_1	0.0833
p.P471S	SIDM01117	Small Cell Lung Carcinoma	GDSC	LPGTPGTT	DEG_SCF_FBW7_1	0.2778
p.P471S	SIDM00210	Ovarian Carcinoma	GDSC	LPGTPGTT	DEG_SCF_FBW7_1	0.2778
p.P452S	ACH-000889	Myeloma	CCLE	LPGTPGTT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09019	Dystrophia myotonica WD repeat-containing protein	DEG_SCF_FBW7_1	462:469	LPGTPGTT	FBXW7	0.9419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons