DegronMD

Uniprot ID: Q09019

Source protein: Dystrophia myotonica WD repeat-containing protein

Source gene: DMWD

Class: DEG_APCC_DBOX_1

Location: 94:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9209

ASA_SCORE: 53.6111

COIL: 0.4866

CONS_SCORE: 0.5542

DSS_SCORE: 0.5797

HELIX: 0.15

FCONS_SCORE: 1.7323

RIG_SCORE: 0.7367

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G84V	DO233680	GACA	ICGC	VRLSLVRLG	DEG_APCC_DBOX_1	0.0556
p.S106R	DO228938	LICA	ICGC	VRLSLVRLG	DEG_APCC_DBOX_1	0.2222
p.S97G	DO229240	THCA	ICGC	VRLSLVRLG	DEG_APCC_DBOX_1	0.5882
p.L96F	DO229250	THCA	ICGC	VRLSLVRLG	DEG_APCC_DBOX_1	0.587
p.G102W	SIDM00927	Small Cell Lung Carcinoma	GDSC	VRLSLVRLG	DEG_APCC_DBOX_1	0.6714
p.G102W	ACH-000871	Lung Cancer	CCLE	VRLSLVRLG	DEG_APCC_DBOX_1	0.6714

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09019	Dystrophia myotonica WD repeat-containing protein	DEG_APCC_DBOX_1	94:102	VRLSLVRLG	APC,CDC20,FZR1	0.9209	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons