DegronMD - Q6DN14(MCTP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q96H	TCGA-ER-A195	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.3056
p.Q96H	DO47712	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.3056
p.N83I	DO44083	BLCA	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation substituting flanking lysine	0.2222
p.V158G	DO6186	BRCA	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.7532
p.L160R	DO49898	CESC	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.8428
p.P14S	DO9114	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.3056
p.P162H	DO8463	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2778
p.P162H	DO40884	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2778
p.S167Y	DO9836	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation blocking phosphorylation signal	0.5833
p.P86A	DO234197	ESAD	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.1944
p.C93S	DO14854	HNSC	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation altering degron motif	0.7541
p.A25D	DO229032	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1667
p.K163E	DO229034	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.25
p.G165R	DO44708	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1944
p.V87M	DO231596	LINC	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.2222
p.N27T	DO231515	LINC	ICGC	AASSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1111
p.V87L	DO45096	LIRI	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.2222
p.V87L	NCI-H1688	lung	COSMIC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.2222
p.A25P	DO23907	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1667
p.I153M	DO230937	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.25
p.I153M	DO224619	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.25
p.W88L	DO26623	LUSC	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.25
p.P147S	DO222434	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0833
p.P147S	DO37851	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0833
p.H98Y	DO222727	MELA	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.25
p.C11G	DO46352	OV	ICGC	AASSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.2222
p.K20I	DO48632	PRAD	ICGC	AASSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.3056
p.P86L	DO36556	READ	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.1944
p.D150N	DO220073	SARC	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1667
p.G26E	DO37639	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	15:19	Mutation substituting flanking lysine	0.25
p.G152E	DO37782	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation blocking phosphorylation signal	0.6667
p.P86H	DO37703	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.1944
p.V96A	DO37406	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.3056
p.W88C	DO37440	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.25
p.W88C	NCI-H1876	lung	COSMIC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.25
p.V96I	DO51242	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.3056
p.E101K	DO219470	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.1667
p.D169N	DO219450	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0833
p.V96F	DO222381	STAD	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.3056
p.Y104H	DO38192	STAD	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.0833
p.A162S	DO229211	THCA	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2778
p.K82N	DO42400	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation substituting flanking lysine	0.1944
p.P86T	DO42713	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.1944
p.L160I	DO42665	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.7174
p.L156R	DO229542	UTCA	ICGC	APSSS	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.8428
p.L88V	SIDM00457	Plasma Cell Myeloma	GDSC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.25
p.L88V	ACH-000024	Myeloma	CCLE	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.25
p.L88V	OPM-2	haematopoietic and lymphoid tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.25
p.F81L	SIDM00679	Cervical Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation rewiring degron network	0.0556
p.S161A	ACH-001648	Prostate Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	156:160	Mutation blocking phosphorylation signal	0.75
p.H93N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation altering degron motif	0.7423
p.I24F	SW684	soft tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1944
p.I94V	SNG-M	endometrium	COSMIC	VFSSS	DEG_SPOP_SBC_1	91:95	Mutation altering degron motif	0.7076

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCTP1

UniProt ID: Q6DN14

Entrez ID: 79772

Protein name: Multiple C2 and transmembrane domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MCTP1 in