DegronMD

Uniprot ID: Q6DN14

Source protein: Multiple C2 and transmembrane domain-containing protein 1

Source gene: MCTP1

Class: DEG_SPOP_SBC_1

Location: 91:95

E3 ligase: SPOP

DEGRON score: 0.9709

ASA_SCORE: 67.6

COIL: 0.7132

CONS_SCORE: 0.308

DSS_SCORE: 0.486

HELIX: 0.0656

FCONS_SCORE: 1.0198

RIG_SCORE: 0.7236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q96H	TCGA-ER-A195	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	0.3056
p.Q96H	DO47712	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	0.3056
p.N83I	DO44083	BLCA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.P86A	DO234197	ESAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1944
p.C93S	DO14854	HNSC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.7541
p.V87M	DO231596	LINC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.V87L	DO45096	LIRI	ICGC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.V87L	NCI-H1688	lung	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.W88L	DO26623	LUSC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.25
p.H98Y	DO222727	MELA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.25
p.P86L	DO36556	READ	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1944
p.P86H	DO37703	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1944
p.V96A	DO37406	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	0.3056
p.W88C	DO37440	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	0.25
p.W88C	NCI-H1876	lung	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.25
p.V96I	DO51242	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	0.3056
p.E101K	DO219470	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1667
p.V96F	DO222381	STAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.3056
p.Y104H	DO38192	STAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0833
p.K82N	DO42400	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1944
p.P86T	DO42713	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1944
p.L88V	SIDM00457	Plasma Cell Myeloma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.25
p.L88V	ACH-000024	Myeloma	CCLE	VFSSS	DEG_SPOP_SBC_1	0.25
p.L88V	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.25
p.F81L	SIDM00679	Cervical Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.0556
p.H93N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.7423
p.I94V	SNG-M	endometrium	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15924	Desmoplakin	DEG_SPOP_SBC_1	2581:2585	VFSSS	SPOP	0.8811	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1454:1458	VFSSS	SPOP	0.9973	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1225:1229	VFSSS	SPOP	0.9959	More...
Q16720	Plasma membrane calcium-transporting ATPase 3	DEG_SPOP_SBC_1	1204:1208	VFSSS	SPOP	0.8618	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	91:95	VFSSS	SPOP	0.9709	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	875:879	VFSSS	SPOP	0.9995	More...
Q9NV56	MRG/MORF4L-binding protein	DEG_SPOP_SBC_1	143:147	VFSSS	SPOP	0.9763	More...
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_SPOP_SBC_1	1058:1062	VFSSS	SPOP	0.9322	More...
P09630	Homeobox protein Hox-C6	DEG_SPOP_SBC_1	62:66	VFSSS	SPOP	0.9955	More...
Q7Z408	CUB and sushi domain-containing protein 2	DEG_SPOP_SBC_1	2911:2915	VFSSS	SPOP	0.6868	More...
Q5T5J6	Transcriptional protein SWT1	DEG_SPOP_SBC_1	740:744	VFSSS	SPOP	0.9982	More...
Q6ZN01	MEF2-activating motif and SAP domain-containing transcriptional regulator	DEG_SPOP_SBC_1	350:354	VFSSS	SPOP	0.9978	More...
Q96ND0	Protein FAM210A	DEG_SPOP_SBC_1	95:99	VFSSS	SPOP	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons