DegronMD - Q7Z408(CSMD2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V2917I	TCGA-AA-3713	COAD	TCGA	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.2778
p.R2903Q	TCGA-AX-A3FT	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1111
p.R2903Q	TCGA-Z2-A8RT	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1111
p.G2923R	TCGA-DA-A1HV	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1111
p.D2907Y	DO5696	BRCA	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.2222
p.Q2901L	DO228815	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.0556
p.R2908S	DO229032	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.25
p.T2905K	DO229045	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1667
p.G2902V	DO231524	LINC	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.0833
p.P2921L	DO23515	LIRI	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1667
p.P2921L	SIDM00582	Pancreatic Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1667
p.P2921L	ACH-000281	Pancreatic Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1667
p.P2921L	KP-2	pancreas	COSMIC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1667
p.P2924T	DO27025	LUSC	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.0833
p.D2903N	DO220889	MELA	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1111
p.H2920Y	DO222702	MELA	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1944
p.H2920D	DO31320	OV	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1944
p.P2924L	DO36342	PRAD	ICGC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.0833
p.P2924L	SIDM00434	Plasma Cell Myeloma	GDSC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.0833
p.P2924L	ACH-000745	Myeloma	CCLE	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.0833
p.P2924L	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.0833
p.L2915F	SIDM00889	Cervical Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation altering degron motif	0.6981
p.L2915F	C-33-A	cervix	COSMIC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation altering degron motif	0.6981
p.G2923E	Sarc9371	bone	COSMIC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation rewiring degron network	0.1111
p.G2912E	A375	skin	COSMIC	VFSSS	DEG_SPOP_SBC_1	2911:2915	Mutation altering degron motif	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSMD2

UniProt ID: Q7Z408

Entrez ID: 114784

Protein name: CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSMD2 in