DegronMD

Uniprot ID: Q7Z408

Source protein: CUB and sushi domain-containing protein 2

Source gene: CSMD2

Class: DEG_SPOP_SBC_1

Location: 2911:2915

E3 ligase: SPOP

DEGRON score: 0.6868

ASA_SCORE: 54.44

COIL: 0.7268

CONS_SCORE: 0.3613

DSS_SCORE: 0.059

HELIX: 0.0078

FCONS_SCORE: 1.0055

RIG_SCORE: 0.8742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2917I	TCGA-AA-3713	COAD	TCGA	VFSSS	DEG_SPOP_SBC_1	0.2778
p.R2903Q	TCGA-AX-A3FT	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1111
p.R2903Q	TCGA-Z2-A8RT	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1111
p.G2923R	TCGA-DA-A1HV	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1111
p.D2907Y	DO5696	BRCA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.Q2901L	DO228815	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0556
p.R2908S	DO229032	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.25
p.T2905K	DO229045	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1667
p.G2902V	DO231524	LINC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0833
p.P2921L	DO23515	LIRI	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1667
p.P2921L	SIDM00582	Pancreatic Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.1667
p.P2921L	ACH-000281	Pancreatic Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	0.1667
p.P2921L	KP-2	pancreas	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.1667
p.P2924T	DO27025	LUSC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0833
p.D2903N	DO220889	MELA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.H2920Y	DO222702	MELA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1944
p.H2920D	DO31320	OV	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1944
p.P2924L	DO36342	PRAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0833
p.P2924L	SIDM00434	Plasma Cell Myeloma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.0833
p.P2924L	ACH-000745	Myeloma	CCLE	VFSSS	DEG_SPOP_SBC_1	0.0833
p.P2924L	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.0833
p.L2915F	SIDM00889	Cervical Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.6981
p.L2915F	C-33-A	cervix	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.6981
p.G2923E	Sarc9371	bone	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.G2912E	A375	skin	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15924	Desmoplakin	DEG_SPOP_SBC_1	2581:2585	VFSSS	SPOP	0.8811	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1454:1458	VFSSS	SPOP	0.9973	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1225:1229	VFSSS	SPOP	0.9959	More...
Q16720	Plasma membrane calcium-transporting ATPase 3	DEG_SPOP_SBC_1	1204:1208	VFSSS	SPOP	0.8618	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	91:95	VFSSS	SPOP	0.9709	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	875:879	VFSSS	SPOP	0.9995	More...
Q9NV56	MRG/MORF4L-binding protein	DEG_SPOP_SBC_1	143:147	VFSSS	SPOP	0.9763	More...
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_SPOP_SBC_1	1058:1062	VFSSS	SPOP	0.9322	More...
P09630	Homeobox protein Hox-C6	DEG_SPOP_SBC_1	62:66	VFSSS	SPOP	0.9955	More...
Q7Z408	CUB and sushi domain-containing protein 2	DEG_SPOP_SBC_1	2911:2915	VFSSS	SPOP	0.6868	More...
Q5T5J6	Transcriptional protein SWT1	DEG_SPOP_SBC_1	740:744	VFSSS	SPOP	0.9982	More...
Q6ZN01	MEF2-activating motif and SAP domain-containing transcriptional regulator	DEG_SPOP_SBC_1	350:354	VFSSS	SPOP	0.9978	More...
Q96ND0	Protein FAM210A	DEG_SPOP_SBC_1	95:99	VFSSS	SPOP	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons