DegronMD - Q07889(SOS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1231V	TCGA-04-1362	OV	TCGA	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.2778
p.S1107Y	TCGA-17-Z022	LUAD	TCGA	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1111
p.P1236S	TCGA-44-A4SS	LUAD	TCGA	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.1389
p.P1236S	DO24227	LUAD	ICGC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.1389
p.L1233I	TCGA-AG-A002	READ	TCGA	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.2222
p.S1103N	TCGA-BP-4967	KIRC	TCGA	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.2222
p.S1103N	DO16795	KIRC	ICGC	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.2222
p.P1237A	TCGA-C5-A7CO	CESC	TCGA	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.1111
p.P1237A	DO49888	CESC	ICGC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.1111
p.P1237A	SIDM01055	Glioblastoma	GDSC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.1111
p.P1237A	GAMG	central nervous system	COSMIC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.1111
p.D1100H	TCGA-DR-A0ZM	CESC	TCGA	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.3056
p.D1100H	DO6254	CESC	ICGC	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.3056
p.P1090L	TCGA-GN-A266	SKCM	TCGA	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.P1090L	DO37432	SKCM	ICGC	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.S1107F	TCGA-Q1-A5R2	CESC	TCGA	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1111
p.S1107F	DO49003	CESC	ICGC	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1111
p.A1095D	DO229028	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation altering degron motif	0.7793
p.H1232N	DO229037	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.25
p.L1216V	DO30260	OV	ICGC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.0833
p.D1228G	DO41331	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation altering degron motif	0.7198
p.S1239P	DO43971	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.0556
p.H1109R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.0556
p.H1109R	ACH-000953	Leukemia	CCLE	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.0556
p.H1109R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.0556
p.R1217Q	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.1111
p.R1217Q	NCI-H2023	lung	COSMIC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.1111
p.S1096T	SIDM00059	Ovarian Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	1095:1099	Mutation altering degron motif	0.6005
p.F1233C	ACH-000697	Lymphoma	CCLE	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.2222
p.F1233C	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation rewiring degron network	0.2222
p.K1226E	PFSK-1	central nervous system	COSMIC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation altering degron motif	0.7022
p.P1222A	GAMG	central nervous system	COSMIC	VFSSS	DEG_SPOP_SBC_1	1225:1229	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for SOS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOS1

UniProt ID: Q07889

Entrez ID: 6654

Protein name: Son of sevenless homolog 1 (SOS-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOS1 in