DegronMD

Uniprot ID: Q07889

Source protein: Son of sevenless homolog 1

Source gene: SOS1

Class: DEG_SPOP_SBC_1

Location: 1225:1229

E3 ligase: SPOP

DEGRON score: 0.9959

ASA_SCORE: 73.34

COIL: 0.9238

CONS_SCORE: 0.2332

DSS_SCORE: 0.6765

HELIX: 0.0458

FCONS_SCORE: 0.9774

RIG_SCORE: 0.6257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1231V	TCGA-04-1362	OV	TCGA	VFSSS	DEG_SPOP_SBC_1	0.2778
p.P1236S	TCGA-44-A4SS	LUAD	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1389
p.P1236S	DO24227	LUAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1389
p.L1233I	TCGA-AG-A002	READ	TCGA	VFSSS	DEG_SPOP_SBC_1	0.2222
p.P1237A	TCGA-C5-A7CO	CESC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1111
p.P1237A	DO49888	CESC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.P1237A	SIDM01055	Glioblastoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.P1237A	GAMG	central_nervous_system	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.H1232N	DO229037	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.25
p.L1216V	DO30260	OV	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0833
p.D1228G	DO41331	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.7198
p.S1239P	DO43971	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0556
p.R1217Q	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.R1217Q	NCI-H2023	lung	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.F1233C	ACH-000697	Lymphoma	CCLE	VFSSS	DEG_SPOP_SBC_1	0.2222
p.F1233C	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.K1226E	PFSK-1	central_nervous_system	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.7022
p.P1222A	GAMG	central_nervous_system	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15924	Desmoplakin	DEG_SPOP_SBC_1	2581:2585	VFSSS	SPOP	0.8811	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1454:1458	VFSSS	SPOP	0.9973	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1225:1229	VFSSS	SPOP	0.9959	More...
Q16720	Plasma membrane calcium-transporting ATPase 3	DEG_SPOP_SBC_1	1204:1208	VFSSS	SPOP	0.8618	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	91:95	VFSSS	SPOP	0.9709	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	875:879	VFSSS	SPOP	0.9995	More...
Q9NV56	MRG/MORF4L-binding protein	DEG_SPOP_SBC_1	143:147	VFSSS	SPOP	0.9763	More...
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_SPOP_SBC_1	1058:1062	VFSSS	SPOP	0.9322	More...
P09630	Homeobox protein Hox-C6	DEG_SPOP_SBC_1	62:66	VFSSS	SPOP	0.9955	More...
Q7Z408	CUB and sushi domain-containing protein 2	DEG_SPOP_SBC_1	2911:2915	VFSSS	SPOP	0.6868	More...
Q5T5J6	Transcriptional protein SWT1	DEG_SPOP_SBC_1	740:744	VFSSS	SPOP	0.9982	More...
Q6ZN01	MEF2-activating motif and SAP domain-containing transcriptional regulator	DEG_SPOP_SBC_1	350:354	VFSSS	SPOP	0.9978	More...
Q96ND0	Protein FAM210A	DEG_SPOP_SBC_1	95:99	VFSSS	SPOP	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons