DegronMD

Uniprot ID: P15924

Source protein: Desmoplakin

Source gene: DSP

Class: DEG_SPOP_SBC_1

Location: 2581:2585

E3 ligase: SPOP

DEGRON score: 0.8811

ASA_SCORE: 63.56

COIL: 0.5658

CONS_SCORE: 0.5157

DSS_SCORE: 0.4106

HELIX: 0.2402

FCONS_SCORE: 1.3484

RIG_SCORE: 0.6882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2585C	TCGA-39-5030	LUSC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.7541
p.S2585C	DO27176	LUSC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.7541
p.G2574R	TCGA-FS-A1ZK	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1389
p.G2574R	DO37474	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1389
p.K2592N	TCGA-NC-A5HG	LUSC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.5833
p.K2592N	DO45448	LUSC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.5833
p.S2575I	DO229025	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1667
p.K2592E	DO45153	LIRI	ICGC	VFSSS	DEG_SPOP_SBC_1	0.5833
p.F2582L	DO52674	MALY	ICGC	VFSSS	DEG_SPOP_SBC_1	0.587
p.S2583I	SIDM01151	Hepatocellular Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.7341
p.S2583I	ACH-000483	Liver Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	0.7341
p.S2583I	SNU-182	liver	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.7341
p.T2595I	ACH-002508	Skin Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15924	Desmoplakin	DEG_SPOP_SBC_1	2581:2585	VFSSS	SPOP	0.8811	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1454:1458	VFSSS	SPOP	0.9973	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1225:1229	VFSSS	SPOP	0.9959	More...
Q16720	Plasma membrane calcium-transporting ATPase 3	DEG_SPOP_SBC_1	1204:1208	VFSSS	SPOP	0.8618	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	91:95	VFSSS	SPOP	0.9709	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	875:879	VFSSS	SPOP	0.9995	More...
Q9NV56	MRG/MORF4L-binding protein	DEG_SPOP_SBC_1	143:147	VFSSS	SPOP	0.9763	More...
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_SPOP_SBC_1	1058:1062	VFSSS	SPOP	0.9322	More...
P09630	Homeobox protein Hox-C6	DEG_SPOP_SBC_1	62:66	VFSSS	SPOP	0.9955	More...
Q7Z408	CUB and sushi domain-containing protein 2	DEG_SPOP_SBC_1	2911:2915	VFSSS	SPOP	0.6868	More...
Q5T5J6	Transcriptional protein SWT1	DEG_SPOP_SBC_1	740:744	VFSSS	SPOP	0.9982	More...
Q6ZN01	MEF2-activating motif and SAP domain-containing transcriptional regulator	DEG_SPOP_SBC_1	350:354	VFSSS	SPOP	0.9978	More...
Q96ND0	Protein FAM210A	DEG_SPOP_SBC_1	95:99	VFSSS	SPOP	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons