DegronMD - Q16720(ATP2B3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1216M	TCGA-23-1117	OV	TCGA	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.1111
p.V1216M	DO30830	OV	ICGC	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.1111
p.I1186T	TCGA-86-A456	LUAD	TCGA	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation rewiring degron network	0.3056
p.I1186T	DO24890	LUAD	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation rewiring degron network	0.3056
p.T1194M	TCGA-AG-3592	READ	TCGA	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation rewiring degron network	0.3056
p.T1194M	TCGA-AG-3592	READ	TCGA	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0556
p.T1194M	DO233903	GACA	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation rewiring degron network	0.3056
p.T1194M	DO233903	GACA	ICGC	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0556
p.T1194M	DO37308	READ	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation rewiring degron network	0.3056
p.T1194M	DO37308	READ	ICGC	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0556
p.L1213F	TCGA-B5-A11J	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.1944
p.L1213F	DO43698	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.1944
p.G1189S	TCGA-BR-4368	STAD	TCGA	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation altering degron motif	0.6993
p.G1189S	DO38715	STAD	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation altering degron motif	0.6993
p.P1177L	TCGA-FS-A4F8	SKCM	TCGA	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation rewiring degron network	0.0556
p.P1177L	DO38117	SKCM	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation rewiring degron network	0.0556
p.S1206F	TCGA-Z2-A8RT	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation altering degron motif	0.7982
p.S1206F	DO51301	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation altering degron motif	0.7982
p.V1196A	SIDM00845	Burkitt's Lymphoma	GDSC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation rewiring degron network	0.25
p.V1196A	SIDM00845	Burkitt's Lymphoma	GDSC	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.1111
p.V1196A	ACH-000786	Lymphoma	CCLE	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation rewiring degron network	0.25
p.V1196A	ACH-000786	Lymphoma	CCLE	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.1111
p.Y1191F	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation altering degron motif	0.6417
p.Y1191F	ACH-000917	Esophageal Cancer	CCLE	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation altering degron motif	0.6417
p.Y1191F	TE-4	oesophagus	COSMIC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation altering degron motif	0.6417
p.P1209H	SIDM01160	Bladder Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.3056
p.P1209H	ACH-000384	Bladder Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.3056
p.P1209H	SW780	urinary tract	COSMIC	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.3056
p.Y1191C	SIDM00976	Melanoma	GDSC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation altering degron motif	0.5976
p.Y1191C	ACH-002205	Skin Cancer	CCLE	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation altering degron motif	0.5976
p.Y1191C	WM1552C	skin	COSMIC	DSGIYLT	DEG_SCF_TRCP1_1	1187:1193	Mutation altering degron motif	0.5976
p.G1210R	SIDM01776	Plasma Cell Myeloma	GDSC	VFSSS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.2778

Kaplan plot for ATP2B3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP2B3

UniProt ID: Q16720

Entrez ID: 492

Protein name: Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP2B3 in