DegronMD

Uniprot ID: Q16720

Source protein: Plasma membrane calcium-transporting ATPase 3

Source gene: ATP2B3

Class: DEG_SCF_TRCP1_1

Location: 1187:1193

E3 ligase: BTRC

DEGRON score: 0.9128

ASA_SCORE: 61.3429

COIL: 0.7383

CONS_SCORE: 0.217

DSS_SCORE: 0.5395

HELIX: 0.1054

FCONS_SCORE: 1.1331

RIG_SCORE: 0.7344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1186T	TCGA-86-A456	LUAD	TCGA	DSGIYLT	DEG_SCF_TRCP1_1	0.3056
p.I1186T	DO24890	LUAD	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	0.3056
p.T1194M	TCGA-AG-3592	READ	TCGA	DSGIYLT	DEG_SCF_TRCP1_1	0.3056
p.T1194M	DO233903	GACA	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	0.3056
p.T1194M	DO37308	READ	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	0.3056
p.G1189S	TCGA-BR-4368	STAD	TCGA	DSGIYLT	DEG_SCF_TRCP1_1	0.6993
p.G1189S	DO38715	STAD	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	0.6993
p.P1177L	TCGA-FS-A4F8	SKCM	TCGA	DSGIYLT	DEG_SCF_TRCP1_1	0.0556
p.P1177L	DO38117	SKCM	ICGC	DSGIYLT	DEG_SCF_TRCP1_1	0.0556
p.V1196A	SIDM00845	Burkitt's Lymphoma	GDSC	DSGIYLT	DEG_SCF_TRCP1_1	0.25
p.V1196A	ACH-000786	Lymphoma	CCLE	DSGIYLT	DEG_SCF_TRCP1_1	0.25
p.Y1191F	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DSGIYLT	DEG_SCF_TRCP1_1	0.6417
p.Y1191F	ACH-000917	Esophageal Cancer	CCLE	DSGIYLT	DEG_SCF_TRCP1_1	0.6417
p.Y1191F	TE-4	oesophagus	COSMIC	DSGIYLT	DEG_SCF_TRCP1_1	0.6417
p.Y1191C	SIDM00976	Melanoma	GDSC	DSGIYLT	DEG_SCF_TRCP1_1	0.5976
p.Y1191C	ACH-002205	Skin Cancer	CCLE	DSGIYLT	DEG_SCF_TRCP1_1	0.5976
p.Y1191C	WM1552C	skin	COSMIC	DSGIYLT	DEG_SCF_TRCP1_1	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16720	Plasma membrane calcium-transporting ATPase 3	DEG_SCF_TRCP1_1	1187:1193	DSGIYLT	BTRC	0.9128	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons