DegronMD - Q5T5J6(SWT1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P547S	TCGA-2W-A8YY	CESC	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1111
p.P547S	DO223732	CESC	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1111
p.H752R	TCGA-55-8208	LUAD	TCGA	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.1111
p.H752R	DO51192	LUAD	ICGC	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.1111
p.L746P	TCGA-75-6211	LUAD	TCGA	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.2778
p.L746P	DO25173	LUAD	ICGC	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.2778
p.K731N	TCGA-AA-A010	COAD	TCGA	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation substituting flanking lysine	0.1944
p.K731N	TCGA-BR-8680	STAD	TCGA	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation substituting flanking lysine	0.1944
p.K731N	DO47769	STAD	ICGC	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation substituting flanking lysine	0.1944
p.S742L	TCGA-AG-A002	READ	TCGA	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation altering degron motif	0.7667
p.S733F	TCGA-AX-A2HC	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.1389
p.S733F	DO41572	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.1389
p.S42L	TCGA-AX-A3FS	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.S42L	DO220860	MELA	ICGC	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.S42L	DO222837	MELA	ICGC	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.S42L	DO40879	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.V740F	TCGA-CV-A6JZ	HNSC	TCGA	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation altering degron motif	0.7068
p.V740F	DO52076	HNSC	ICGC	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation altering degron motif	0.7068
p.K566N	TCGA-D3-A2JC	SKCM	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation substituting flanking lysine	0.3333
p.K566N	DO47578	SKCM	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation substituting flanking lysine	0.3333
p.K566M	TCGA-DD-AADF	LIHC	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation substituting flanking lysine	0.3333
p.K566M	DO52232	LIHC	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation substituting flanking lysine	0.3333
p.K555R	TCGA-EC-A24G	UCEC	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation altering degron motif	0.6126
p.K555R	DO40996	UCEC	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation altering degron motif	0.6126
p.P747S	TCGA-FR-A728	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.25
p.P747S	DO48550	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.25
p.P550H	TCGA-IB-7651	PAAD	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1944
p.P550H	DO46657	PAAD	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1944
p.S49L	TCGA-JX-A3Q0	CESC	TCGA	PASST	DEG_SPOP_SBC_1	36:40	Mutation blocking phosphorylation signal	0.5278
p.S49L	DO51607	CESC	ICGC	PASST	DEG_SPOP_SBC_1	36:40	Mutation blocking phosphorylation signal	0.5278
p.I549V	TCGA-VQ-A8P2	STAD	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1667
p.I549V	DO51761	STAD	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1667
p.R751K	TCGA-XU-A936	THYM	TCGA	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.1389
p.E754K	DO222421	BTCA	ICGC	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.0556
p.S38I	DO229022	LICA	ICGC	PASST	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7341
p.S43F	DO220898	MELA	ICGC	PASST	DEG_SPOP_SBC_1	36:40	Mutation blocking phosphorylation signal	0.6944
p.K566E	DO222363	MELA	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation substituting flanking lysine	0.3333
p.T739I	SIDM02025	Colorectal Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.3056
p.E568D	SIDM00683	Prostate Carcinoma	GDSC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1667
p.E568D	ACH-000977	lymph node	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1667
p.E568D	LNCaP-Clone-FGC	prostate	COSMIC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1667
p.S43Y	SIDM00773	Non-Cancerous	GDSC	PASST	DEG_SPOP_SBC_1	36:40	Mutation blocking phosphorylation signal	0.6944
p.S43Y	SIDM00210	Ovarian Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	36:40	Mutation blocking phosphorylation signal	0.6944
p.S43Y	SIDM00774	Breast Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	36:40	Mutation blocking phosphorylation signal	0.6944
p.S43Y	SIDM01409	Bladder Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	36:40	Mutation blocking phosphorylation signal	0.6944
p.S50L	SIDM00107	Melanoma	GDSC	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.S50L	ACH-000425	Skin Cancer	CCLE	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.S50L	ACH-002004	Skin Cancer	CCLE	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.S50L	UACC-62	skin	COSMIC	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.P550S	SIDM00003	Melanoma	GDSC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1944
p.P550S	ACH-000884	Skin Cancer	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1944
p.P550S	ACH-002159	Skin Cancer	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1944
p.P550S	M14	skin	COSMIC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1944
p.S44Y	SIDM01611	Endometrial Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2222
p.S44Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2222
p.S569F	SIDM01619	Endometrial Carcinoma	GDSC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1389
p.S569F	ACH-000984	Endometrial/Uterine Cancer	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.1389
p.T35P	ACH-001669	Leukemia	CCLE	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.3056
p.T35P	ACH-002238	Leukemia	CCLE	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.3056
p.T35P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PASST	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.3056
p.S572F	ACH-001991	Primary	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	555:562	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SWT1

UniProt ID: Q5T5J6

Entrez ID: 54823

Protein name: Transcriptional protein SWT1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SWT1 in