DegronMD

Uniprot ID: Q5T5J6

Source protein: Transcriptional protein SWT1

Source gene: SWT1

Class: DEG_SPOP_SBC_1

Location: 740:744

E3 ligase: SPOP

DEGRON score: 0.9982

ASA_SCORE: 81.64

COIL: 0.7824

CONS_SCORE: 0.3485

DSS_SCORE: 0.5627

HELIX: 0.1564

FCONS_SCORE: 1.105

RIG_SCORE: 0.7367

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H752R	TCGA-55-8208	LUAD	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1111
p.H752R	DO51192	LUAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.L746P	TCGA-75-6211	LUAD	TCGA	VFSSS	DEG_SPOP_SBC_1	0.2778
p.L746P	DO25173	LUAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.2778
p.K731N	TCGA-AA-A010	COAD	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1944
p.K731N	TCGA-BR-8680	STAD	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1944
p.K731N	DO47769	STAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1944
p.S742L	TCGA-AG-A002	READ	TCGA	VFSSS	DEG_SPOP_SBC_1	0.7667
p.S733F	TCGA-AX-A2HC	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1389
p.S733F	DO41572	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1389
p.V740F	TCGA-CV-A6JZ	HNSC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.7068
p.V740F	DO52076	HNSC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.7068
p.P747S	TCGA-FR-A728	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	0.25
p.P747S	DO48550	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	0.25
p.R751K	TCGA-XU-A936	THYM	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1389
p.E754K	DO222421	BTCA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0556
p.T739I	SIDM02025	Colorectal Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15924	Desmoplakin	DEG_SPOP_SBC_1	2581:2585	VFSSS	SPOP	0.8811	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1454:1458	VFSSS	SPOP	0.9973	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1225:1229	VFSSS	SPOP	0.9959	More...
Q16720	Plasma membrane calcium-transporting ATPase 3	DEG_SPOP_SBC_1	1204:1208	VFSSS	SPOP	0.8618	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	91:95	VFSSS	SPOP	0.9709	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	875:879	VFSSS	SPOP	0.9995	More...
Q9NV56	MRG/MORF4L-binding protein	DEG_SPOP_SBC_1	143:147	VFSSS	SPOP	0.9763	More...
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_SPOP_SBC_1	1058:1062	VFSSS	SPOP	0.9322	More...
P09630	Homeobox protein Hox-C6	DEG_SPOP_SBC_1	62:66	VFSSS	SPOP	0.9955	More...
Q7Z408	CUB and sushi domain-containing protein 2	DEG_SPOP_SBC_1	2911:2915	VFSSS	SPOP	0.6868	More...
Q5T5J6	Transcriptional protein SWT1	DEG_SPOP_SBC_1	740:744	VFSSS	SPOP	0.9982	More...
Q6ZN01	MEF2-activating motif and SAP domain-containing transcriptional regulator	DEG_SPOP_SBC_1	350:354	VFSSS	SPOP	0.9978	More...
Q96ND0	Protein FAM210A	DEG_SPOP_SBC_1	95:99	VFSSS	SPOP	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons