DegronMD - Q6ZN01(MAMSTR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A56V	TCGA-AA-3864	COAD	TCGA	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation altering degron motif	0.5825
p.A56V	DO8490	COAD	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation altering degron motif	0.5825
p.S53A	TCGA-CA-6717	COAD	TCGA	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation altering degron motif	0.6477
p.S53A	DO8264	COAD	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation altering degron motif	0.6477
p.S53L	TCGA-EO-A22T	UCEC	TCGA	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation altering degron motif	0.6556
p.S353Y	TCGA-FI-A2D5	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.712
p.K68T	DO222798	COCA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation rewiring degron network	0.1111
p.E68K	DO234311	ESAD	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation rewiring degron network	0.1111
p.P47H	DO233189	GACA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation altering degron motif	0.7694
p.P62T	DO229018	LICA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation rewiring degron network	0.2778
p.S61R	DO229025	LICA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation rewiring degron network	0.3056
p.M40I	DO36881	READ	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation rewiring degron network	0.1389
p.V64L	DO229221	THCA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation rewiring degron network	0.2222
p.P67S	SIDM00587	Biliary Tract Carcinoma	GDSC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation rewiring degron network	0.1389
p.L66V	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	47:60	Mutation rewiring degron network	0.1667
p.P364L	SIDM01617	Endometrial Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.P364L	ACH-000994	Endometrial/Uterine Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.P340S	SIDM01617	Endometrial Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.P340S	ACH-000994	Endometrial/Uterine Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556

Kaplan plot for MAMSTR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAMSTR

UniProt ID: Q6ZN01

Entrez ID: 284358

Protein name: MEF2-activating motif and SAP domain-containing transcriptional regulator (MEF2-activating SAP transcriptional regulatory protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAMSTR in