DegronMD

Uniprot ID: Q6ZN01

Source protein: MEF2-activating motif and SAP domain-containing transcriptional regulator

Source gene: MAMSTR

Class: DEG_ODPH_VHL_1

Location: 47:60

E3 ligase: VHL

DEGRON score: 0.8687

ASA_SCORE: 65.75

COIL: 0.8609

CONS_SCORE: 0.7632

DSS_SCORE: 0.447

HELIX: 0.0678

FCONS_SCORE: 0.9219

RIG_SCORE: 0.6599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A56V	TCGA-AA-3864	COAD	TCGA	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.5825
p.A56V	DO8490	COAD	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.5825
p.S53A	TCGA-CA-6717	COAD	TCGA	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.6477
p.S53A	DO8264	COAD	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.6477
p.S53L	TCGA-EO-A22T	UCEC	TCGA	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.6556
p.K68T	DO222798	COCA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.1111
p.E68K	DO234311	ESAD	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.1111
p.P47H	DO233189	GACA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.7694
p.P62T	DO229018	LICA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.2778
p.S61R	DO229025	LICA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.3056
p.M40I	DO36881	READ	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.1389
p.V64L	DO229221	THCA	ICGC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.2222
p.P67S	SIDM00587	Biliary Tract Carcinoma	GDSC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.1389
p.L66V	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LAPALPSGTAPFLF	DEG_ODPH_VHL_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZN01	MEF2-activating motif and SAP domain-containing transcriptional regulator	DEG_ODPH_VHL_1	47:60	LAPALPSGTAPFLF	VHL	0.8687	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons