DegronMD - P15924(DSP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2585C	TCGA-39-5030	LUSC	TCGA	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation altering degron motif	0.7541
p.S2585C	DO27176	LUSC	ICGC	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation altering degron motif	0.7541
p.G2574R	TCGA-FS-A1ZK	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation rewiring degron network	0.1389
p.G2574R	DO37474	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation rewiring degron network	0.1389
p.K2592N	TCGA-NC-A5HG	LUSC	TCGA	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation blocking ubiquitination signal	0.5833
p.K2592N	DO45448	LUSC	ICGC	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation blocking ubiquitination signal	0.5833
p.S2575I	DO229025	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation rewiring degron network	0.1667
p.K2592E	DO45153	LIRI	ICGC	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation blocking ubiquitination signal	0.5833
p.F2582L	DO52674	MALY	ICGC	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation altering degron motif	0.587
p.S2583I	SIDM01151	Hepatocellular Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation altering degron motif	0.7341
p.S2583I	ACH-000483	Liver Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation altering degron motif	0.7341
p.S2583I	SNU-182	liver	COSMIC	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation altering degron motif	0.7341
p.T2595I	ACH-002508	Skin Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	2581:2585	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons