DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SPOP_SBC_1

Location: 1454:1458

E3 ligase: SPOP

DEGRON score: 0.9973

ASA_SCORE: 75.02

COIL: 0.8532

CONS_SCORE: 0.3386

DSS_SCORE: 0.4271

HELIX: 0.0288

FCONS_SCORE: 0.9071

RIG_SCORE: 0.6977

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1457C	TCGA-56-7822	LUSC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.8652
p.S1457C	DO26638	LUSC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.8652
p.F1462L	TCGA-AP-A0LM	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.2222
p.F1462L	DO1101	BRCA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.F1462L	DO43306	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	SIDM00607	Glioblastoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	SIDM00251	Gastric Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	SIDM00564	Ovarian Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	SIDM01575	Plasma Cell Myeloma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	SIDM00162	Biliary Tract Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	TGBC11TKB	stomach	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	LU-99A	lung	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	KNS-42	central_nervous_system	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.G1466C	OVISE	ovary	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.S1462L	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.S1462L	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.2222
p.V1454M	ACH-000980	Lung Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	0.7208
p.V1454M	NCI-H1155	lung	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15924	Desmoplakin	DEG_SPOP_SBC_1	2581:2585	VFSSS	SPOP	0.8811	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1454:1458	VFSSS	SPOP	0.9973	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1225:1229	VFSSS	SPOP	0.9959	More...
Q16720	Plasma membrane calcium-transporting ATPase 3	DEG_SPOP_SBC_1	1204:1208	VFSSS	SPOP	0.8618	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	91:95	VFSSS	SPOP	0.9709	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	875:879	VFSSS	SPOP	0.9995	More...
Q9NV56	MRG/MORF4L-binding protein	DEG_SPOP_SBC_1	143:147	VFSSS	SPOP	0.9763	More...
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_SPOP_SBC_1	1058:1062	VFSSS	SPOP	0.9322	More...
P09630	Homeobox protein Hox-C6	DEG_SPOP_SBC_1	62:66	VFSSS	SPOP	0.9955	More...
Q7Z408	CUB and sushi domain-containing protein 2	DEG_SPOP_SBC_1	2911:2915	VFSSS	SPOP	0.6868	More...
Q5T5J6	Transcriptional protein SWT1	DEG_SPOP_SBC_1	740:744	VFSSS	SPOP	0.9982	More...
Q6ZN01	MEF2-activating motif and SAP domain-containing transcriptional regulator	DEG_SPOP_SBC_1	350:354	VFSSS	SPOP	0.9978	More...
Q96ND0	Protein FAM210A	DEG_SPOP_SBC_1	95:99	VFSSS	SPOP	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons