DegronMD

Uniprot ID: Q9NV56

Source protein: MRG/MORF4L-binding protein

Source gene: MRGBP

Class: DEG_SPOP_SBC_1

Location: 143:147

E3 ligase: SPOP

DEGRON score: 0.9763

ASA_SCORE: 77.36

COIL: 0.8262

CONS_SCORE: 0.4249

DSS_SCORE: 0.646

HELIX: 0.1098

FCONS_SCORE: 0.9436

RIG_SCORE: 0.657

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S157C	TCGA-91-6828	LUAD	TCGA	VFSSS	DEG_SPOP_SBC_1	0.0556
p.S157C	DO26150	LUAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0556
p.D135N	TCGA-AA-3663	COAD	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1111
p.D135N	DO9346	COAD	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.A153S	TCGA-B5-A11E	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.1667
p.A153S	DO41644	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.1667
p.S157F	TCGA-B5-A3FC	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	0.0556
p.S157F	DO41871	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	0.0556
p.S149N	TCGA-TQ-A7RU	LGG	TCGA	VFSSS	DEG_SPOP_SBC_1	0.7222
p.S149N	DO223698	LGG	ICGC	VFSSS	DEG_SPOP_SBC_1	0.7222
p.S145L	DO222864	COCA	ICGC	VFSSS	DEG_SPOP_SBC_1	0.7667
p.S154L	SIDM00845	Burkitt's Lymphoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.1389
p.S154L	SIDM00461	Acute Myeloid Leukemia	GDSC	VFSSS	DEG_SPOP_SBC_1	0.1389
p.S154L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VFSSS	DEG_SPOP_SBC_1	0.1389
p.S154L	SIDM01519	Head and Neck Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.1389
p.S154L	ACH-000786	Lymphoma	CCLE	VFSSS	DEG_SPOP_SBC_1	0.1389
p.S154L	ACH-000992	Head and Neck Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	0.1389
p.S154L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	0.1389
p.D135E	SIDM00681	Colorectal Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.D135E	SIDM01641	Non-Cancerous	GDSC	VFSSS	DEG_SPOP_SBC_1	0.1111
p.D135E	ACH-000252	Colon/Colorectal Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	0.1111
p.D135E	ACH-002376	Non-Cancerous	CCLE	VFSSS	DEG_SPOP_SBC_1	0.1111
p.S157P	ACH-000960	Leukemia	CCLE	VFSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15924	Desmoplakin	DEG_SPOP_SBC_1	2581:2585	VFSSS	SPOP	0.8811	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1454:1458	VFSSS	SPOP	0.9973	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1225:1229	VFSSS	SPOP	0.9959	More...
Q16720	Plasma membrane calcium-transporting ATPase 3	DEG_SPOP_SBC_1	1204:1208	VFSSS	SPOP	0.8618	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	91:95	VFSSS	SPOP	0.9709	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	875:879	VFSSS	SPOP	0.9995	More...
Q9NV56	MRG/MORF4L-binding protein	DEG_SPOP_SBC_1	143:147	VFSSS	SPOP	0.9763	More...
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_SPOP_SBC_1	1058:1062	VFSSS	SPOP	0.9322	More...
P09630	Homeobox protein Hox-C6	DEG_SPOP_SBC_1	62:66	VFSSS	SPOP	0.9955	More...
Q7Z408	CUB and sushi domain-containing protein 2	DEG_SPOP_SBC_1	2911:2915	VFSSS	SPOP	0.6868	More...
Q5T5J6	Transcriptional protein SWT1	DEG_SPOP_SBC_1	740:744	VFSSS	SPOP	0.9982	More...
Q6ZN01	MEF2-activating motif and SAP domain-containing transcriptional regulator	DEG_SPOP_SBC_1	350:354	VFSSS	SPOP	0.9978	More...
Q96ND0	Protein FAM210A	DEG_SPOP_SBC_1	95:99	VFSSS	SPOP	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons