DegronMD - Q9NV56(MRGBP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S157C	TCGA-91-6828	LUAD	TCGA	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0556
p.S157C	DO26150	LUAD	ICGC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0556
p.D135N	TCGA-AA-3663	COAD	TCGA	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.D135N	DO9346	COAD	ICGC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.A153S	TCGA-B5-A11E	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1667
p.A153S	DO41644	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1667
p.S157F	TCGA-B5-A3FC	UCEC	TCGA	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0556
p.S157F	DO41871	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0556
p.S149N	TCGA-TQ-A7RU	LGG	TCGA	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation blocking phosphorylation signal	0.7222
p.S149N	DO223698	LGG	ICGC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation blocking phosphorylation signal	0.7222
p.S145L	DO222864	COCA	ICGC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.7667
p.S154L	SIDM00845	Burkitt's Lymphoma	GDSC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.S154L	SIDM00461	Acute Myeloid Leukemia	GDSC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.S154L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.S154L	SIDM01519	Head and Neck Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.S154L	ACH-000786	Lymphoma	CCLE	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.S154L	ACH-000992	Head and Neck Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.S154L	Daudi	haematopoietic and lymphoid tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.D135E	SIDM00681	Colorectal Carcinoma	GDSC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.D135E	SIDM01641	Non-Cancerous	GDSC	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.D135E	ACH-000252	Colon/Colorectal Cancer	CCLE	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.D135E	ACH-002376	Non-Cancerous	CCLE	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.S157P	ACH-000960	Leukemia	CCLE	VFSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0556

Kaplan plot for MRGBP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MRGBP

UniProt ID: Q9NV56

Entrez ID: 55257

Protein name: MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MRGBP in