DegronMD - P09630(HOXC6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S76Y	TCGA-25-1326	OV	TCGA	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.S76Y	DO28154	OV	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.P53H	TCGA-33-4532	LUSC	TCGA	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7694
p.P53H	DO26626	LUSC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7694
p.S51W	TCGA-4Z-AA87	BLCA	TCGA	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.6763
p.S76C	TCGA-50-5044	LUAD	TCGA	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.Y70C	TCGA-B0-5707	KIRC	TCGA	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2222
p.Y70C	DO20733	KIRC	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2222
p.W43L	DO2694	BRCA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1667
p.R63C	DO5521	BRCA	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.8301
p.G62V	DO233107	GACA	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7532
p.Y41H	DO17303	KIRC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1111
p.P42T	DO219688	KIRP	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1389
p.R63L	DO229035	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.8428
p.R63L	DO229041	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.8428
p.R63L	DO229045	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.8428
p.M47I	DO44674	LICA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.2778
p.S49L	DO222420	MELA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7667
p.S49L	DO35083	PACA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7667
p.S49L	DO41758	UCEC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7667
p.S49L	NCI-H1568	lung	COSMIC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7667
p.P53S	DO222702	MELA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.6752
p.I65L	DO31899	OV	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7174
p.S67L	DO218874	SKCA	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.3056
p.H50L	DO51298	SKCM	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7313
p.I49F	DO38404	STAD	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7415
p.G54S	DO43626	UCEC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.6993
p.Y41C	DO41644	UCEC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1111
p.Y69H	DO43907	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.25
p.G56R	DO41145	UCEC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7568
p.S67P	DO41331	UCEC	ICGC	VFSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.3056
p.G41R	SIDM00608	Plasma Cell Myeloma	GDSC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1111
p.G41R	ACH-000714	Myeloma	CCLE	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1111
p.G41R	KMS-11	haematopoietic and lymphoid tissue	COSMIC	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1111
p.A45V	ACH-001991	Primary	CCLE	IYSTPFYS	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.2222

Kaplan plot for HOXC6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXC6

UniProt ID: P09630

Entrez ID: 3223

Protein name: Homeobox protein Hox-C6 (Homeobox protein CP25) (Homeobox protein HHO.C8) (Homeobox protein Hox-3C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXC6 in