DegronMD

Uniprot ID: P09630

Source protein: Homeobox protein Hox-C6

Source gene: HOXC6

Class: DEG_SCF_FBW7_1

Location: 49:56

E3 ligase: FBXW7

DEGRON score: 0.573

ASA_SCORE: 65.625

COIL: 0.9024

CONS_SCORE: 0.7248

DSS_SCORE: 0.2582

HELIX: 0.0203

FCONS_SCORE: 1.1115

RIG_SCORE: 0.811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P53H	TCGA-33-4532	LUSC	TCGA	IYSTPFYS	DEG_SCF_FBW7_1	0.7694
p.P53H	DO26626	LUSC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.7694
p.S51W	TCGA-4Z-AA87	BLCA	TCGA	IYSTPFYS	DEG_SCF_FBW7_1	0.6763
p.W43L	DO2694	BRCA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.1667
p.Y41H	DO17303	KIRC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.1111
p.P42T	DO219688	KIRP	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.1389
p.M47I	DO44674	LICA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.2778
p.S49L	DO222420	MELA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.7667
p.S49L	DO35083	PACA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.7667
p.S49L	DO41758	UCEC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.7667
p.S49L	NCI-H1568	lung	COSMIC	IYSTPFYS	DEG_SCF_FBW7_1	0.7667
p.P53S	DO222702	MELA	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.6752
p.H50L	DO51298	SKCM	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.7313
p.I49F	DO38404	STAD	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.7415
p.G54S	DO43626	UCEC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.6993
p.Y41C	DO41644	UCEC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.1111
p.G56R	DO41145	UCEC	ICGC	IYSTPFYS	DEG_SCF_FBW7_1	0.7568
p.G41R	SIDM00608	Plasma Cell Myeloma	GDSC	IYSTPFYS	DEG_SCF_FBW7_1	0.1111
p.G41R	ACH-000714	Myeloma	CCLE	IYSTPFYS	DEG_SCF_FBW7_1	0.1111
p.G41R	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	IYSTPFYS	DEG_SCF_FBW7_1	0.1111
p.A45V	ACH-001991	Primary	CCLE	IYSTPFYS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09630	Homeobox protein Hox-C6	DEG_SCF_FBW7_1	49:56	IYSTPFYS	FBXW7	0.573	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons