DegronMD

Uniprot ID: Q5T5J6

Source protein: Transcriptional protein SWT1

Source gene: SWT1

Class: DEG_SCF_SKP2-CKS1_1

Location: 555:562

E3 ligase: SKP2,CSK1

DEGRON score: 0.8001

ASA_SCORE: 98.2375

COIL: 0.7394

CONS_SCORE: 0.3636

DSS_SCORE: 0.4645

HELIX: 0.2336

FCONS_SCORE: 1.1364

RIG_SCORE: 0.7484

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P547S	TCGA-2W-A8YY	CESC	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P547S	DO223732	CESC	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.K566N	TCGA-D3-A2JC	SKCM	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.3333
p.K566N	DO47578	SKCM	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.3333
p.K566M	TCGA-DD-AADF	LIHC	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.3333
p.K566M	DO52232	LIHC	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.3333
p.K555R	TCGA-EC-A24G	UCEC	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.6126
p.K555R	DO40996	UCEC	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.6126
p.P550H	TCGA-IB-7651	PAAD	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P550H	DO46657	PAAD	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.I549V	TCGA-VQ-A8P2	STAD	TCGA	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.I549V	DO51761	STAD	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.K566E	DO222363	MELA	ICGC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.3333
p.E568D	SIDM00683	Prostate Carcinoma	GDSC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E568D	ACH-000977	lymph_node	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E568D	LNCaP-Clone-FGC	prostate	COSMIC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P550S	SIDM00003	Melanoma	GDSC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P550S	ACH-000884	Skin Cancer	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P550S	ACH-002159	Skin Cancer	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P550S	M14	skin	COSMIC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S569F	SIDM01619	Endometrial Carcinoma	GDSC	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S569F	ACH-000984	Endometrial/Uterine Cancer	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S572F	ACH-001991	Primary	CCLE	KAETTPLK	DEG_SCF_SKP2-CKS1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5J6	Transcriptional protein SWT1	DEG_SCF_SKP2-CKS1_1	555:562	KAETTPLK	SKP2,CSK1	0.8001	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons