DegronMD - O00499(BIN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V494M	TCGA-AJ-A3BH	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1944
p.E496D	TCGA-FI-A2D5	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1389
p.P349Q	TCGA-FI-A2F4	UCEC	TCGA	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.7035
p.S489Y	TCGA-GJ-A9DB	LIHC	TCGA	AASSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.712
p.R495S	DO453	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1667
p.G353S	DO224647	BRCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.3056
p.G358A	DO1885	BRCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.1667
p.V487I	DO223703	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7076
p.P356L	DO229013	COCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.2222
p.S344R	DO229029	LICA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.3056
p.P356S	DO50970	LICA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.2222
p.G358R	DO38147	SKCM	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.1667
p.S361G	DO229253	THCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.0833
p.S354N	DO229245	THCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.2778
p.A352V	DO229250	THCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.6936
p.V494L	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1944
p.V494L	ACH-000666	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1944
p.V494L	NCI-H1355	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1944
p.P345H	ACH-000690	Lung Cancer	CCLE	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.7694
p.H347R	ACH-001414	Bladder Cancer	CCLE	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.7133
p.R336Q	ACH-001459	Colon/Colorectal Cancer	CCLE	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.0833
p.V340L	NCI-H1355	lung	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.1944
p.R495K	T47D	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1667
p.R480K	T47D	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1944
p.F477L	EN	endometrium	COSMIC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1111
p.P476H	TGBC11TKB	stomach	COSMIC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.0833
p.D361N	SW837	large intestine	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.0833
p.P476S	IGR-1	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.0833
p.R360H	LU-65	lung	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.1111
p.V355L	NCI-H1355	lung	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.25
p.F492L	EN	endometrium	COSMIC	AASSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.25
p.R345H	LU-65	lung	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.8244

Kaplan plot for BIN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BIN1

UniProt ID: O00499

Entrez ID: 274

Protein name: Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BIN1 in