DegronMD

Uniprot ID: O00499

Source protein: Myc box-dependent-interacting protein 1

Source gene: BIN1

Class: DEG_SCF_FBW7_2

Location: 345:352

E3 ligase: FBXW7

DEGRON score: 0.7568

ASA_SCORE: 105.725

COIL: 0.8696

CONS_SCORE: 0.3422

DSS_SCORE: 0.7618

HELIX: 0.1066

FCONS_SCORE: 0.9922

RIG_SCORE: 0.6012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P349Q	TCGA-FI-A2F4	UCEC	TCGA	PKHTPSKE	DEG_SCF_FBW7_2	0.7035
p.G353S	DO224647	BRCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	0.3056
p.G358A	DO1885	BRCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	0.1667
p.P356L	DO229013	COCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	0.2222
p.S344R	DO229029	LICA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	0.3056
p.P356S	DO50970	LICA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	0.2222
p.G358R	DO38147	SKCM	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	0.1667
p.S361G	DO229253	THCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	0.0833
p.S354N	DO229245	THCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	0.2778
p.A352V	DO229250	THCA	ICGC	PKHTPSKE	DEG_SCF_FBW7_2	0.6936
p.P345H	ACH-000690	Lung Cancer	CCLE	PKHTPSKE	DEG_SCF_FBW7_2	0.7694
p.H347R	ACH-001414	Bladder Cancer	CCLE	PKHTPSKE	DEG_SCF_FBW7_2	0.7133
p.R336Q	ACH-001459	Colon/Colorectal Cancer	CCLE	PKHTPSKE	DEG_SCF_FBW7_2	0.0833
p.V340L	NCI-H1355	lung	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	0.1944
p.D361N	SW837	large_intestine	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	0.0833
p.R360H	LU-65	lung	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	0.1111
p.V355L	NCI-H1355	lung	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	0.25
p.R345H	LU-65	lung	COSMIC	PKHTPSKE	DEG_SCF_FBW7_2	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00499	Myc box-dependent-interacting protein 1	DEG_SCF_FBW7_2	345:352	PKHTPSKE	FBXW7	0.7568	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons