DegronMD - Q7Z5M5(TMC3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K780N	TCGA-78-7152	LUAD	TCGA	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.5806
p.Q1053H	TCGA-AP-A056	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.25
p.M791I	TCGA-AP-A1DK	UCEC	TCGA	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.0556
p.P1036S	TCGA-AX-A1C4	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.E1040K	TCGA-D3-A1Q6	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1667
p.E1040K	SIDM00140	Melanoma	GDSC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1667
p.E1040K	ACH-000968	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1667
p.E1040K	COLO-792	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1667
p.A1057T	TCGA-FI-A2D5	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1389
p.A1057T	SIDM01619	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1389
p.A1057T	ACH-000984	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1389
p.A788T	TCGA-VM-A8CA	LGG	TCGA	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1389
p.G770D	DO228319	BRCA	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1944
p.A789T	DO50248	LGG	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1111
p.S780R	DO228948	LICA	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.7427
p.N769K	DO228952	LICA	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1667
p.P766H	DO229045	LICA	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.0833
p.Q1060E	DO45301	LIRI	ICGC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.K781N	DO23560	LUAD	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.6918
p.E1041K	DO37450	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1944
p.E1041K	COLO-792	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1944
p.E1036K	DO47331	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.T765I	DO42608	UCEC	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.0556
p.P1037S	DO42480	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0833
p.A1058T	DO41331	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1111
p.Q1054H	DO43971	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2222
p.N768S	SIDM01090	Colorectal Carcinoma	GDSC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1389
p.N768S	ACH-000943	Colon/Colorectal Cancer	CCLE	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1389
p.N768S	RKO	large intestine	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1389
p.G777E	SIDM00151	Ovarian Carcinoma	GDSC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.7199
p.G777E	ACH-000966	Ovarian Cancer	CCLE	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.7199
p.G777E	IGROV-1	ovary	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.7199
p.I784T	SIDM00112	Kidney Carcinoma	GDSC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.25
p.I784T	ACH-000428	Kidney Cancer	CCLE	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.25
p.I784T	U031	kidney	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.25
p.S1037F	SIDM00177	Melanoma	GDSC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0833
p.S1037F	ACH-002338	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0833
p.S1037F	ACH-002510	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0833
p.E785K	SIDM01052	Ovarian Carcinoma	GDSC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.2222
p.E785K	ACH-000308	Ovarian Cancer	CCLE	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.2222
p.E785K	EFO-21	ovary	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.2222
p.S1050T	SIDM01700	Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	1046:1050	Mutation altering degron motif	0.6005
p.N769S	RKO	large intestine	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1667
p.I785T	U031	kidney	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.2222
p.E786K	EFO-21	ovary	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1944
p.G778E	IGROV-1	ovary	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMC3

UniProt ID: Q7Z5M5

Entrez ID: 342125

Protein name: Transmembrane channel-like protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMC3 in