DegronMD

Uniprot ID: Q7Z5M5

Source protein: Transmembrane channel-like protein 3

Source gene: TMC3

Class: DEG_SCF_TRCP1_1

Location: 775:781

E3 ligase: BTRC

DEGRON score: 0.9534

ASA_SCORE: 80.5571

COIL: 0.8954

CONS_SCORE: 0.3875

DSS_SCORE: 0.6708

HELIX: 0.0643

FCONS_SCORE: 1.0087

RIG_SCORE: 0.5742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K780N	TCGA-78-7152	LUAD	TCGA	DSGSSKS	DEG_SCF_TRCP1_1	0.5806
p.M791I	TCGA-AP-A1DK	UCEC	TCGA	DSGSSKS	DEG_SCF_TRCP1_1	0.0556
p.A788T	TCGA-VM-A8CA	LGG	TCGA	DSGSSKS	DEG_SCF_TRCP1_1	0.1389
p.G770D	DO228319	BRCA	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	0.1944
p.A789T	DO50248	LGG	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	0.1111
p.S780R	DO228948	LICA	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	0.7427
p.N769K	DO228952	LICA	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	0.1667
p.P766H	DO229045	LICA	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	0.0833
p.K781N	DO23560	LUAD	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	0.6918
p.T765I	DO42608	UCEC	ICGC	DSGSSKS	DEG_SCF_TRCP1_1	0.0556
p.N768S	SIDM01090	Colorectal Carcinoma	GDSC	DSGSSKS	DEG_SCF_TRCP1_1	0.1389
p.N768S	ACH-000943	Colon/Colorectal Cancer	CCLE	DSGSSKS	DEG_SCF_TRCP1_1	0.1389
p.N768S	RKO	large_intestine	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	0.1389
p.G777E	SIDM00151	Ovarian Carcinoma	GDSC	DSGSSKS	DEG_SCF_TRCP1_1	0.7199
p.G777E	ACH-000966	Ovarian Cancer	CCLE	DSGSSKS	DEG_SCF_TRCP1_1	0.7199
p.G777E	IGROV-1	ovary	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	0.7199
p.I784T	SIDM00112	Kidney Carcinoma	GDSC	DSGSSKS	DEG_SCF_TRCP1_1	0.25
p.I784T	ACH-000428	Kidney Cancer	CCLE	DSGSSKS	DEG_SCF_TRCP1_1	0.25
p.I784T	U031	kidney	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	0.25
p.E785K	SIDM01052	Ovarian Carcinoma	GDSC	DSGSSKS	DEG_SCF_TRCP1_1	0.2222
p.E785K	ACH-000308	Ovarian Cancer	CCLE	DSGSSKS	DEG_SCF_TRCP1_1	0.2222
p.E785K	EFO-21	ovary	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	0.2222
p.N769S	RKO	large_intestine	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	0.1667
p.I785T	U031	kidney	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	0.2222
p.E786K	EFO-21	ovary	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	0.1944
p.G778E	IGROV-1	ovary	COSMIC	DSGSSKS	DEG_SCF_TRCP1_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5M5	Transmembrane channel-like protein 3	DEG_SCF_TRCP1_1	775:781	DSGSSKS	BTRC	0.9534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSSKS

Degron related mutations and impact score

Drug responses associated with TMC3 mutations

All proteins holding degron of DSGSSKS