DegronMD - Q9UHC7(MKRN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T123A	TCGA-13-0757	OV	TCGA	AASSS	DEG_SPOP_SBC_1	129:133	Mutation blocking phosphorylation signal	0.6111
p.A25T	TCGA-AD-6895	COAD	TCGA	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.25
p.A25T	DO8938	COAD	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.25
p.L134I	TCGA-AP-A0LM	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.P140S	TCGA-AX-A1CE	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.S127C	TCGA-DQ-5631	HNSC	TCGA	AASSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.G32R	DO10582	COAD	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation altering degron motif	0.7568
p.R31Q	DO233941	GACA	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation altering degron motif	0.7329
p.T35N	DO229028	LICA	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.2778
p.T120K	DO229022	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.G43E	DO24130	LUAD	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0556
p.A43V	DO45546	LUSC	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0556
p.A125T	DO220901	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	129:133	Mutation substituting flanking lysine	0.3333
p.T35P	DO229167	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.2778
p.A41G	DO229180	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1111
p.A41G	DO229204	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1111
p.A41G	DO229084	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1111
p.L39P	DO229264	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1667
p.A142T	DO41584	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.V34I	SIDM02039	Colorectal Carcinoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.3056
p.A18G	SIDM00607	Glioblastoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0556
p.A18G	SIDM00552	Rhabdomyosarcoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0556
p.A18G	SIDM00425	Ovarian Carcinoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0556
p.V138A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.V138A	ACH-002256	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.V138A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.A129V	SIDM00837	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.5825
p.A129V	ACH-000958	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.5825
p.A129V	SW48	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.5825
p.S126L	SIDM00176	Chondrosarcoma	GDSC	AASSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.25
p.P30Q	SIDM00273	Glioblastoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation altering degron motif	0.7035
p.A23T	SIDM00980	Gastric Carcinoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1944
p.A23T	ACH-000948	Gastric Cancer	CCLE	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.1944
p.V131G	NCI-H748	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7532
p.D19V	ONS-76	central nervous system	COSMIC	PTPIPT	DEG_SCF_FBW7_1	28:33	Mutation rewiring degron network	0.0833

Kaplan plot for MKRN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MKRN1

UniProt ID: Q9UHC7

Entrez ID: 23608

Protein name: E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MKRN1 in