DegronMD

Uniprot ID: Q9UHC7

Source protein: E3 ubiquitin-protein ligase makorin-1

Source gene: MKRN1

Class: DEG_SCF_FBW7_1

Location: 28:33

E3 ligase: FBXW7

DEGRON score: 0.9779

ASA_SCORE: 88.3

COIL: 0.9642

CONS_SCORE: 0.1971

DSS_SCORE: 0.4775

HELIX: 0.0092

FCONS_SCORE: 0.9878

RIG_SCORE: 0.714

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A25T	TCGA-AD-6895	COAD	TCGA	PTPIPT	DEG_SCF_FBW7_1	0.25
p.A25T	DO8938	COAD	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.25
p.G32R	DO10582	COAD	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.7568
p.R31Q	DO233941	GACA	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.7329
p.T35N	DO229028	LICA	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.2778
p.G43E	DO24130	LUAD	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.0556
p.A43V	DO45546	LUSC	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.0556
p.T35P	DO229167	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.2778
p.A41G	DO229180	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.1111
p.A41G	DO229204	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.1111
p.A41G	DO229084	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.1111
p.L39P	DO229264	THCA	ICGC	PTPIPT	DEG_SCF_FBW7_1	0.1667
p.V34I	SIDM02039	Colorectal Carcinoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	0.3056
p.A18G	SIDM00607	Glioblastoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	0.0556
p.A18G	SIDM00552	Rhabdomyosarcoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	0.0556
p.A18G	SIDM00425	Ovarian Carcinoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	0.0556
p.P30Q	SIDM00273	Glioblastoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	0.7035
p.A23T	SIDM00980	Gastric Carcinoma	GDSC	PTPIPT	DEG_SCF_FBW7_1	0.1944
p.A23T	ACH-000948	Gastric Cancer	CCLE	PTPIPT	DEG_SCF_FBW7_1	0.1944
p.D19V	ONS-76	central_nervous_system	COSMIC	PTPIPT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHC7	E3 ubiquitin-protein ligase makorin-1	DEG_SCF_FBW7_1	28:33	PTPIPT	FBXW7	0.9779	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons