DegronMD - Q96SF7(TBX15)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y481F	TCGA-25-2391	OV	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1944
p.Y481F	DO31769	OV	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1944
p.P485S	TCGA-3N-A9WD	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.3056
p.P485S	TCGA-FW-A3R5	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.3056
p.P485S	DO37406	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.3056
p.P485S	DO51235	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.3056
p.G309W	TCGA-50-7109	LUAD	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation altering degron motif	0.7825
p.G309W	DO24487	LUAD	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation altering degron motif	0.7825
p.D312H	TCGA-55-7570	LUAD	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.2778
p.D312H	DO25280	LUAD	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.2778
p.S487Y	TCGA-64-5779	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.712
p.S487Y	DO24930	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.712
p.S487Y	DO224563	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.712
p.V60L	TCGA-68-8250	LUSC	TCGA	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.2222
p.V60L	DO26993	LUSC	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.2222
p.R68I	TCGA-A5-A0G1	UCEC	TCGA	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.8102
p.R68I	DO42472	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.8102
p.I59F	TCGA-AB-2802	LAML	TCGA	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.1944
p.I59F	DO21845	LAML	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.1944
p.V70A	TCGA-AJ-A3EK	UCEC	TCGA	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.3056
p.V70A	DO41584	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.3056
p.A483T	TCGA-AO-A0J4	BRCA	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.A483T	DO1559	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P485T	TCGA-AP-A1E0	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.3056
p.P485T	DO43154	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.3056
p.R298Q	TCGA-B5-A0JY	UCEC	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.1667
p.R298Q	TCGA-D1-A15X	UCEC	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.1667
p.R298Q	DO43041	UCEC	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.1667
p.R298Q	DO43274	UCEC	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.1667
p.D477N	TCGA-D3-A5GO	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.D477N	DO47419	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.M495I	TCGA-EE-A3JD	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1944
p.M495I	DO50299	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1944
p.K65T	TCGA-EO-A3B0	UCEC	TCGA	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.7306
p.K65T	DO219773	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.7306
p.G482R	TCGA-FS-A1ZM	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2222
p.G482R	DO37731	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2222
p.P485L	TCGA-FW-A3R5	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.3056
p.P485L	DO229123	NKTL	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.3056
p.P485L	DO37406	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.3056
p.A297S	TCGA-OR-A5JA	ACC	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.1389
p.R66I	DO8264	COAD	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.8102
p.R479Q	DO8360	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1389
p.A60V	DO233156	GACA	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.2222
p.S299G	DO47072	RECA	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.1944
p.L304V	DO218874	SKCA	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation altering degron motif	0.6765
p.P68L	DO229264	THCA	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.6471
p.D77Y	DO43202	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.1111
p.D77Y	DO43186	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.1111
p.A589V	SIDM01169	Ovarian Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2778
p.A589V	ACH-000885	Ovarian Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2778
p.A589V	TOV-21G	ovary	COSMIC	PGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2778
p.P493A	SIDM00672	Hepatocellular Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM00846	Cervical Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM00650	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM01147	Gastric Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM00793	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM01681	Non-Cancerous	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM00808	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM01173	Rhabdomyosarcoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM01686	Chronic Myelogenous Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.P493A	SIDM01254	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.S499C	SIDM01126	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.S499C	ACH-001599	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.S499C	NCI-H64	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.G306E	SIDM01175	Other Sarcomas	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation altering degron motif	0.7199
p.G306E	ACH-002309	Sarcoma	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation altering degron motif	0.7199
p.G306E	SW684	soft tissue	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation altering degron motif	0.7199
p.T318K	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.1111
p.V599M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.V599M	ACH-000953	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.R303I	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.3056
p.R303I	ACH-000922	Leukemia	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.3056
p.R303I	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.3056
p.R303K	SIDM01060	Melanoma	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.3056
p.R303K	ACH-000882	Skin Cancer	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.3056
p.R303K	IGR-1	skin	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.3056
p.V599L	SIDM00294	Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.V599L	ACH-001549	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.V599L	LU-135	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.R295Q	SIDM00217	Colorectal Carcinoma	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.0833
p.R295Q	ACH-000068	Lymphoma	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.0833
p.R295Q	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.0833
p.R295Q	SNU-1040	large intestine	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.0833
p.R303G	SIDM01608	Endometrial Carcinoma	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.3056
p.R303G	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.3056
p.G54R	ACH-000932	Gastric Cancer	CCLE	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.0556
p.I315T	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation rewiring degron network	0.1944
p.L304W	HEL	haematopoietic and lymphoid tissue	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	304:310	Mutation altering degron motif	0.7015
p.I59L	NCI-SNU-5	stomach	COSMIC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.1944
p.V493L	LU-135	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.Y54C	RKO	large intestine	COSMIC	LEPHPD	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.0556
p.A483V	TOV-21G	ovary	COSMIC	AASSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBX15

UniProt ID: Q96SF7

Entrez ID: 6913

Protein name: T-box transcription factor TBX15 (T-box protein 15) (T-box transcription factor TBX14) (T-box protein 14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBX15 in