DegronMD

Uniprot ID: Q96SF7

Source protein: T-box transcription factor TBX15

Source gene: TBX15

Class: LIG_APCC_ABBA_1

Location: 64:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7798

ASA_SCORE: 95.2667

COIL: 0.9165

CONS_SCORE: 0.5049

DSS_SCORE: 0.8209

HELIX: 0.0602

FCONS_SCORE: 1.0395

RIG_SCORE: 0.5911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V60L	TCGA-68-8250	LUSC	TCGA	LEPHPD	LIG_APCC_ABBA_1	0.2222
p.V60L	DO26993	LUSC	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.2222
p.R68I	TCGA-A5-A0G1	UCEC	TCGA	LEPHPD	LIG_APCC_ABBA_1	0.8102
p.R68I	DO42472	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.8102
p.I59F	TCGA-AB-2802	LAML	TCGA	LEPHPD	LIG_APCC_ABBA_1	0.1944
p.I59F	DO21845	LAML	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.1944
p.V70A	TCGA-AJ-A3EK	UCEC	TCGA	LEPHPD	LIG_APCC_ABBA_1	0.3056
p.V70A	DO41584	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.3056
p.K65T	TCGA-EO-A3B0	UCEC	TCGA	LEPHPD	LIG_APCC_ABBA_1	0.7306
p.K65T	DO219773	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.7306
p.R66I	DO8264	COAD	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.8102
p.A60V	DO233156	GACA	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.2222
p.P68L	DO229264	THCA	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.6471
p.D77Y	DO43202	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.1111
p.D77Y	DO43186	UCEC	ICGC	LEPHPD	LIG_APCC_ABBA_1	0.1111
p.G54R	ACH-000932	Gastric Cancer	CCLE	LEPHPD	LIG_APCC_ABBA_1	0.0556
p.I59L	NCI-SNU-5	stomach	COSMIC	LEPHPD	LIG_APCC_ABBA_1	0.1944
p.Y54C	RKO	large_intestine	COSMIC	LEPHPD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SF7	T-box transcription factor TBX15	LIG_APCC_ABBA_1	64:69	LEPHPD	APC,CDC20,FZR1	0.7798	More...
Q9C0D2	Centrosomal protein of 295 kDa	LIG_APCC_ABBA_1	2082:2087	LEPHPD	APC,CDC20,FZR1	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons