DegronMD

Uniprot ID: Q9C0D2

Source protein: Centrosomal protein of 295 kDa

Source gene: CEP295

Class: LIG_APCC_ABBA_1

Location: 2082:2087

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9914

ASA_SCORE: 101.05

COIL: 0.9295

CONS_SCORE: 0.5142

DSS_SCORE: 0.5099

HELIX: 0.0363

FCONS_SCORE: 1.2221

RIG_SCORE: 0.6629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2091P	SIDM00986	Head and Neck Carcinoma	GDSC	LEPHPD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SF7	T-box transcription factor TBX15	LIG_APCC_ABBA_1	64:69	LEPHPD	APC,CDC20,FZR1	0.7798	More...
Q9C0D2	Centrosomal protein of 295 kDa	LIG_APCC_ABBA_1	2082:2087	LEPHPD	APC,CDC20,FZR1	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons