DegronMD

Uniprot ID: Q96SF7

Source protein: T-box transcription factor TBX15

Source gene: TBX15

Class: DEG_SCF_TRCP1_1

Location: 304:310

E3 ligase: BTRC

DEGRON score: 0.8151

ASA_SCORE: 87.4

COIL: 0.8256

CONS_SCORE: 0.5939

DSS_SCORE: 0.4054

HELIX: 0.1446

FCONS_SCORE: 0.9024

RIG_SCORE: 0.7044

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G309W	TCGA-50-7109	LUAD	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	0.7825
p.G309W	DO24487	LUAD	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	0.7825
p.D312H	TCGA-55-7570	LUAD	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	0.2778
p.D312H	DO25280	LUAD	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	0.2778
p.R298Q	TCGA-B5-A0JY	UCEC	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	0.1667
p.R298Q	TCGA-D1-A15X	UCEC	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	0.1667
p.R298Q	DO43041	UCEC	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	0.1667
p.R298Q	DO43274	UCEC	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	0.1667
p.A297S	TCGA-OR-A5JA	ACC	TCGA	DSGRNRT	DEG_SCF_TRCP1_1	0.1389
p.S299G	DO47072	RECA	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	0.1944
p.L304V	DO218874	SKCA	ICGC	DSGRNRT	DEG_SCF_TRCP1_1	0.6765
p.G306E	SIDM01175	Other Sarcomas	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	0.7199
p.G306E	ACH-002309	Sarcoma	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	0.7199
p.G306E	SW684	soft_tissue	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	0.7199
p.T318K	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	0.1111
p.R303I	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	0.3056
p.R303I	ACH-000922	Leukemia	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	0.3056
p.R303I	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	0.3056
p.R303K	SIDM01060	Melanoma	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	0.3056
p.R303K	ACH-000882	Skin Cancer	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	0.3056
p.R303K	IGR-1	skin	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	0.3056
p.R295Q	SIDM00217	Colorectal Carcinoma	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	0.0833
p.R295Q	ACH-000068	Lymphoma	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	0.0833
p.R295Q	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	0.0833
p.R295Q	SNU-1040	large_intestine	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	0.0833
p.R303G	SIDM01608	Endometrial Carcinoma	GDSC	DSGRNRT	DEG_SCF_TRCP1_1	0.3056
p.R303G	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	0.3056
p.I315T	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGRNRT	DEG_SCF_TRCP1_1	0.1944
p.L304W	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRNRT	DEG_SCF_TRCP1_1	0.7015

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRNRT

Degron related mutations and impact score

Drug responses associated with TBX15 mutations

All proteins holding degron of DSGRNRT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SF7	T-box transcription factor TBX15	DEG_SCF_TRCP1_1	304:310	DSGRNRT	BTRC	0.8151	More...