DegronMD - Q15464(SHB)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P23S	TCGA-RD-A7BT	STAD	TCGA	DYR	CBL_MET	26:28	Mutation rewiring degron network	0.25
p.P23S	DO50131	STAD	ICGC	DYR	CBL_MET	26:28	Mutation rewiring degron network	0.25
p.S155F	DO228483	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.S155F	SIDM01061	Oral Cavity Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.S155F	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.S155F	SIDM00368	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.S155F	SIDM01446	Glioblastoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.S155F	SIDM01378	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.S155F	SIDM00500	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.R33G	DO30970	OV	ICGC	DYR	CBL_MET	26:28	Mutation rewiring degron network	0.1944
p.A83T	DO229240	THCA	ICGC	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1944
p.H160D	SIDM00417	Plasma Cell Myeloma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.A146T	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.A146T	SIDM01180	Hepatocellular Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.A146T	SIDM00032	Bladder Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.A146T	SIDM01018	Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.D72H	SIDM00596	Endometrial Carcinoma	GDSC	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.3056
p.D72H	SIDM00576	Acute Myeloid Leukemia	GDSC	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.3056
p.D72H	SIDM00239	Kidney Carcinoma	GDSC	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.3056
p.D72H	SIDM00171	Colorectal Carcinoma	GDSC	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.3056
p.L161V	SIDM01157	Other Solid Cancers	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1111
p.L161V	SIDM00220	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1111
p.L161V	SIDM00638	Cervical Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1111
p.S38L	SIDM00006	Other Solid Cancers	GDSC	DYR	CBL_MET	26:28	Mutation rewiring degron network	0.0556
p.S38L	ACH-001552	Skin Cancer	CCLE	DYR	CBL_MET	26:28	Mutation rewiring degron network	0.0556
p.G75D	SIDM00537	Colorectal Carcinoma	GDSC	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.7198
p.G75D	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.7198
p.G75D	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.7198
p.K88N	ACH-000214	Non-Cancerous	CCLE	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation substituting flanking lysine	0.1667
p.S74G	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGSTS	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.6993
p.S18T	ACH-001607	Gallbladder Cancer	CCLE	DYR	CBL_MET	26:28	Mutation blocking phosphorylation signal	0.5556

Kaplan plot for SHB in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHB

UniProt ID: Q15464

Entrez ID: 6461

Protein name: SH2 domain-containing adapter protein B

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SHB in