DegronMD

Uniprot ID: Q15464

Source protein: SH2 domain-containing adapter protein B

Source gene: SHB

Class: DEG_SCF_TRCP1_1

Location: 73:78

E3 ligase: BTRC

DEGRON score: 0.8506

ASA_SCORE: 71.1167

COIL: 0.7763

CONS_SCORE: 0.4965

DSS_SCORE: 0.5147

HELIX: 0.2013

FCONS_SCORE: 1.0007

RIG_SCORE: 0.6274

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A83T	DO229240	THCA	ICGC	DSGSTS	DEG_SCF_TRCP1_1	0.1944
p.D72H	SIDM00596	Endometrial Carcinoma	GDSC	DSGSTS	DEG_SCF_TRCP1_1	0.3056
p.D72H	SIDM00576	Acute Myeloid Leukemia	GDSC	DSGSTS	DEG_SCF_TRCP1_1	0.3056
p.D72H	SIDM00239	Kidney Carcinoma	GDSC	DSGSTS	DEG_SCF_TRCP1_1	0.3056
p.D72H	SIDM00171	Colorectal Carcinoma	GDSC	DSGSTS	DEG_SCF_TRCP1_1	0.3056
p.G75D	SIDM00537	Colorectal Carcinoma	GDSC	DSGSTS	DEG_SCF_TRCP1_1	0.7198
p.G75D	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGSTS	DEG_SCF_TRCP1_1	0.7198
p.G75D	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGSTS	DEG_SCF_TRCP1_1	0.7198
p.K88N	ACH-000214	Non-Cancerous	CCLE	DSGSTS	DEG_SCF_TRCP1_1	0.1667
p.S74G	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGSTS	DEG_SCF_TRCP1_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15464	SH2 domain-containing adapter protein B	DEG_SCF_TRCP1_1	73:78	DSGSTS	BTRC	0.8506	More...
Q96S94	Cyclin-L2	DEG_SCF_TRCP1_1	407:412	DSGSTS	BTRC	0.9802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons