DegronMD

Uniprot ID: Q96S94

Source protein: Cyclin-L2

Source gene: CCNL2

Class: DEG_SCF_TRCP1_1

Location: 407:412

E3 ligase: BTRC

DEGRON score: 0.9802

ASA_SCORE: 89.1333

COIL: 0.9752

CONS_SCORE: 0.2777

DSS_SCORE: 0.8394

HELIX: 0.0162

FCONS_SCORE: 1.0085

RIG_SCORE: 0.414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R422W	TCGA-AN-A0G0	BRCA	TCGA	DSGSTS	DEG_SCF_TRCP1_1	0.0556
p.G413S	TCGA-AZ-6601	COAD	TCGA	DSGSTS	DEG_SCF_TRCP1_1	0.3056
p.R422Q	SIDM00217	Colorectal Carcinoma	GDSC	DSGSTS	DEG_SCF_TRCP1_1	0.0556
p.R422Q	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGSTS	DEG_SCF_TRCP1_1	0.0556
p.R422Q	SNU-1040	large_intestine	COSMIC	DSGSTS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15464	SH2 domain-containing adapter protein B	DEG_SCF_TRCP1_1	73:78	DSGSTS	BTRC	0.8506	More...
Q96S94	Cyclin-L2	DEG_SCF_TRCP1_1	407:412	DSGSTS	BTRC	0.9802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons