DegronMD - O94851(MICAL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P917A	TCGA-05-4424	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.3056
p.P917A	DO23672	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.3056
p.P902L	TCGA-BF-A1PZ	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0556
p.P902L	DO50279	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0556
p.L474V	TCGA-CD-8531	STAD	TCGA	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.1389
p.L474V	DO47877	STAD	ICGC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.1389
p.P467T	TCGA-EB-A299	SKCM	TCGA	NKNFEQYTLDP	CBL_PTK	457:467	Mutation altering degron motif	0.7031
p.P467T	DO37794	SKCM	ICGC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation altering degron motif	0.7031
p.R470L	TCGA-EE-A2MS	SKCM	TCGA	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.25
p.R470L	DO37567	SKCM	ICGC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.25
p.P925S	TCGA-EE-A2MS	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0833
p.P925S	DO37567	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0833
p.R470Q	TCGA-EY-A549	UCEC	TCGA	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.25
p.R470Q	DO48174	UCEC	ICGC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.25
p.P467Q	TCGA-FS-A1ZC	SKCM	TCGA	NKNFEQYTLDP	CBL_PTK	457:467	Mutation altering degron motif	0.7035
p.P467Q	DO37487	SKCM	ICGC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation altering degron motif	0.7035
p.T451A	TCGA-VQ-AA6D	STAD	TCGA	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.1667
p.T451A	DO222392	STAD	ICGC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.1667
p.S907Y	DO1285	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1944
p.S907Y	DO6308	CESC	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1944
p.A912T	DO222955	BTCA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.7139
p.A912T	DO47849	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.7139
p.C907R	DO8842	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1944
p.P907L	DO227709	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1944
p.P907L	DO234336	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1944
p.P907L	DO220891	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1944
p.F924L	DO48328	ESCA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1111
p.A923S	DO49662	LIAD	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1389
p.R905L	DO229015	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1389
p.A912S	DO229028	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.7588
p.G914C	DO229028	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.76
p.A913S	DO229026	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.6477
p.R922S	DO229035	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1667
p.F460S	DO50951	LICA	ICGC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation altering degron motif	0.6871
p.S907C	DO49718	LIHC	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1944
p.T915I	DO218922	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.7078
p.P920L	DO23631	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2222
p.E454K	DO232761	PBCA	ICGC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.25
p.G918D	DO47837	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.P920T	DO41014	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2222
p.D910N	SIDM00360	Other Solid Cancers	GDSC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.D910N	SIDM00214	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.D910N	ACH-000347	Pancreatic Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.D910N	ACH-000955	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.D910N	QGP-1	pancreas	COSMIC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.D910N	SNU-407	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.T450N	SIDM00882	Breast Carcinoma	GDSC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.1389
p.A456S	SIDM00497	Colorectal Carcinoma	GDSC	NKNFEQYTLDP	CBL_PTK	457:467	Mutation rewiring degron network	0.3056
p.A912V	NCI-H2126	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.5825
p.A1755T	LS-411N	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	1755:1759	Mutation altering degron motif	0.7139
p.S1278L	IA-LM	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	1276:1280	Mutation altering degron motif	0.7667
p.S1278L	LC-2-ad	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	1276:1280	Mutation altering degron motif	0.7667
p.R904M	NCI-H1568	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1111

Kaplan plot for MICAL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MICAL2

UniProt ID: O94851

Entrez ID: 9645

Protein name: [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MICAL2 in