DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NKNFEQYTLDP
Uniprot ID:
O94851
Source protein:
[F-actin]-monooxygenase MICAL2
Source gene:
MICAL2
Class:
CBL_PTK
Location:
457:467
E3 ligase:
CBL
DEGRON score:
0.751
ASA_SCORE:
67.0909
COIL:
0.5716
CONS_SCORE:
0.6188
DSS_SCORE:
0.4868
HELIX:
0.2689
FCONS_SCORE:
1.0744
RIG_SCORE:
0.7714
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L474V
TCGA-CD-8531
STAD
TCGA
NKNFEQYTLDP
CBL_PTK
0.1389
p.L474V
DO47877
STAD
ICGC
NKNFEQYTLDP
CBL_PTK
0.1389
p.P467T
TCGA-EB-A299
SKCM
TCGA
NKNFEQYTLDP
CBL_PTK
0.7031
p.P467T
DO37794
SKCM
ICGC
NKNFEQYTLDP
CBL_PTK
0.7031
p.R470L
TCGA-EE-A2MS
SKCM
TCGA
NKNFEQYTLDP
CBL_PTK
0.25
p.R470L
DO37567
SKCM
ICGC
NKNFEQYTLDP
CBL_PTK
0.25
p.R470Q
TCGA-EY-A549
UCEC
TCGA
NKNFEQYTLDP
CBL_PTK
0.25
p.R470Q
DO48174
UCEC
ICGC
NKNFEQYTLDP
CBL_PTK
0.25
p.P467Q
TCGA-FS-A1ZC
SKCM
TCGA
NKNFEQYTLDP
CBL_PTK
0.7035
p.P467Q
DO37487
SKCM
ICGC
NKNFEQYTLDP
CBL_PTK
0.7035
p.T451A
TCGA-VQ-AA6D
STAD
TCGA
NKNFEQYTLDP
CBL_PTK
0.1667
p.T451A
DO222392
STAD
ICGC
NKNFEQYTLDP
CBL_PTK
0.1667
p.F460S
DO50951
LICA
ICGC
NKNFEQYTLDP
CBL_PTK
0.6871
p.E454K
DO232761
PBCA
ICGC
NKNFEQYTLDP
CBL_PTK
0.25
p.T450N
SIDM00882
Breast Carcinoma
GDSC
NKNFEQYTLDP
CBL_PTK
0.1389
p.A456S
SIDM00497
Colorectal Carcinoma
GDSC
NKNFEQYTLDP
CBL_PTK
0.3056
Drug responses associated with MICAL2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NKNFEQYTLDP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94851
[F-actin]-monooxygenase MICAL2
CBL_PTK
457:467
NKNFEQYTLDP
CBL
0.751
More...
