DegronMD - Q6UWI4(SHISA2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P258L	TCGA-91-6828	LUAD	TCGA	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.2222
p.P258L	DO26150	LUAD	ICGC	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.2222
p.A197V	TCGA-AP-A051	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.A197V	DO42673	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.A197V	SIDM00680	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.A197V	ACH-000095	Brain Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.A197V	ACH-000957	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.A197V	LS-180	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.P264R	TCGA-B5-A3FA	UCEC	TCGA	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.7512
p.P264R	DO52402	UCEC	ICGC	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.7512
p.S176L	TCGA-B7-A5TJ	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.S176L	TCGA-RW-A67V	PCPG	TCGA	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.S176L	DO222329	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.S178L	TCGA-BF-AAP4	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.S178L	DO219468	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.Q277H	TCGA-BQ-5893	KIRP	TCGA	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.Q277H	DO20895	KIRP	ICGC	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.V252M	TCGA-BR-8485	STAD	TCGA	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.V252M	DO47823	STAD	ICGC	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.R174Q	TCGA-D3-A8GM	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174Q	TCGA-EA-A3HS	CESC	TCGA	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174Q	DO6260	CESC	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174Q	DO50288	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174Q	SIDM00383	Gastric Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174W	TCGA-E2-A105	BRCA	TCGA	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174W	DO3536	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174W	SIDM00217	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174W	SNU-1040	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.N192S	TCGA-EO-A22U	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2222
p.N192S	DO43755	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2222
p.D255N	TCGA-FS-A1ZA	SKCM	TCGA	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.1389
p.D255N	DO37551	SKCM	ICGC	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.1389
p.G268D	TCGA-HU-A4H3	STAD	TCGA	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.3056
p.G268D	DO47903	STAD	ICGC	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.3056
p.A195T	TCGA-YD-A89C	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.A195T	DO219501	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.R196Q	DO233116	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.R196Q	DO228349	MALY	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.R196Q	SIDM00656	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.R196Q	SIDM00050	Chondrosarcoma	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.R196Q	SIDM00641	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.R196Q	ACH-000944	Lymphoma	CCLE	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.R196Q	ACH-002093	Bone Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.R196Q	CHSA0108	bone	COSMIC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.R196Q	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.A197E	DO228474	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.A197E	DO228806	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.S189T	DO228827	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.3056
p.G175V	DO232000	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.RG174RR	DO220906	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0
p.D267N	DO220906	MELA	ICGC	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.6932
p.G175R	DO220906	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.R174P	SIDM01156	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174P	ACH-000890	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.R174P	SW1271	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.G268S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VPPFMD	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.3056
p.R179C	SIDM00049	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.A195S	SIDM00730	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.A195S	ACH-000610	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.A195S	NCI-H2227	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.S178P	SIDM00451	T-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.S178P	ACH-000937	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.S178P	PF-382	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHISA2

UniProt ID: Q6UWI4

Entrez ID: 387914

Protein name: Protein shisa-2 homolog (Transmembrane protein 46)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHISA2 in