DegronMD

Uniprot ID: Q6UWI4

Source protein: Protein shisa-2 homolog

Source gene: SHISA2

Class: LIG_APCC_ABBA_1

Location: 262:267

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.922

ASA_SCORE: 63.5667

COIL: 0.7657

CONS_SCORE: 0.6738

DSS_SCORE: 0.4591

HELIX: 0.1862

FCONS_SCORE: 1.1397

RIG_SCORE: 0.7635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P258L	TCGA-91-6828	LUAD	TCGA	VPPFMD	LIG_APCC_ABBA_1	0.2222
p.P258L	DO26150	LUAD	ICGC	VPPFMD	LIG_APCC_ABBA_1	0.2222
p.P264R	TCGA-B5-A3FA	UCEC	TCGA	VPPFMD	LIG_APCC_ABBA_1	0.7512
p.P264R	DO52402	UCEC	ICGC	VPPFMD	LIG_APCC_ABBA_1	0.7512
p.Q277H	TCGA-BQ-5893	KIRP	TCGA	VPPFMD	LIG_APCC_ABBA_1	0.0556
p.Q277H	DO20895	KIRP	ICGC	VPPFMD	LIG_APCC_ABBA_1	0.0556
p.V252M	TCGA-BR-8485	STAD	TCGA	VPPFMD	LIG_APCC_ABBA_1	0.0556
p.V252M	DO47823	STAD	ICGC	VPPFMD	LIG_APCC_ABBA_1	0.0556
p.D255N	TCGA-FS-A1ZA	SKCM	TCGA	VPPFMD	LIG_APCC_ABBA_1	0.1389
p.D255N	DO37551	SKCM	ICGC	VPPFMD	LIG_APCC_ABBA_1	0.1389
p.G268D	TCGA-HU-A4H3	STAD	TCGA	VPPFMD	LIG_APCC_ABBA_1	0.3056
p.G268D	DO47903	STAD	ICGC	VPPFMD	LIG_APCC_ABBA_1	0.3056
p.D267N	DO220906	MELA	ICGC	VPPFMD	LIG_APCC_ABBA_1	0.6932
p.G268S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VPPFMD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UWI4	Protein shisa-2 homolog	LIG_APCC_ABBA_1	262:267	VPPFMD	APC,CDC20,FZR1	0.922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons