DegronMD - Q9H329(EPB41L4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V812L	TCGA-05-5425	LUAD	TCGA	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.25
p.V812L	DO26270	LUAD	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.25
p.S481L	TCGA-24-1565	OV	TCGA	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7667
p.S481L	DO31719	OV	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7667
p.D379N	TCGA-AA-3510	COAD	TCGA	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation rewiring degron network	0.1667
p.D379N	DO7783	COAD	ICGC	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation rewiring degron network	0.1667
p.A363T	TCGA-AJ-A3BH	UCEC	TCGA	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation rewiring degron network	0.2222
p.A363T	DO41638	UCEC	ICGC	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation rewiring degron network	0.2222
p.R483Q	TCGA-AP-A056	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R483Q	DO43971	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.P811L	TCGA-AX-A3GB	UCEC	TCGA	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.2222
p.P811L	DO41121	UCEC	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.2222
p.T369M	TCGA-D1-A174	UCEC	TCGA	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation altering degron motif	0.8534
p.T369M	DO40900	UCEC	ICGC	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation altering degron motif	0.8534
p.G371E	TCGA-D3-A1QA	SKCM	TCGA	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation altering degron motif	0.6087
p.G371E	DO47469	SKCM	ICGC	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation altering degron motif	0.6087
p.R483W	TCGA-DU-6392	LGG	TCGA	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R483W	DO234257	ESAD	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R483W	DO22237	LGG	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.P474H	TCGA-EE-A29Q	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.P474H	DO37866	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.T821I	TCGA-IH-A3EA	SKCM	TCGA	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.3056
p.T821I	DO37667	SKCM	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.3056
p.D379Y	TCGA-KQ-A41N	BLCA	TCGA	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation rewiring degron network	0.1667
p.D379Y	DO223588	BLCA	ICGC	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation rewiring degron network	0.1667
p.P817L	TCGA-W3-AA1V	SKCM	TCGA	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.6471
p.P817L	DO51276	SKCM	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.6471
p.P817S	TCGA-W3-AA1V	SKCM	TCGA	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.6752
p.P817S	DO51276	SKCM	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.6752
p.S478L	DO9386	COAD	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7667
p.N816T	DO229010	COCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.5944
p.N816T	DO229016	COCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.5944
p.N816T	DO229003	COCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.5944
p.N816T	DO229005	COCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.5944
p.R368W	DO233857	GACA	ICGC	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation altering degron motif	0.7523
p.A482E	DO228948	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.3056
p.T369K	DO229026	LICA	ICGC	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation altering degron motif	0.8417
p.P467Q	DO229038	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0556
p.S475F	DO222908	MELA	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R477S	DO232761	PBCA	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7427
p.G486A	DO51738	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1944
p.G825W	DO229268	THCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1944
p.S483L	DO42472	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.S475Y	SIDM00281	Other Solid Cancers	GDSC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.S475Y	ACH-002100	Skin Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.S475Y	DJM-1	skin	COSMIC	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.G825E	SIDM00007	Other Solid Cancers	GDSC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1944
p.G825E	ACH-001550	Skin Cancer	CCLE	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1944
p.G825E	MCC13	skin	COSMIC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1944
p.Q827P	SIDM00193	Colorectal Carcinoma	GDSC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1389
p.Q827P	SIDM00488	Colorectal Carcinoma	GDSC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1389
p.Q827P	ACH-000991	Colon/Colorectal Cancer	CCLE	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1389
p.Q827P	ACH-002345	Colon/Colorectal Cancer	CCLE	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1389
p.Q827P	SNU-81	large intestine	COSMIC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1389
p.Q827P	CaR-1	large intestine	COSMIC	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.1389
p.H362N	SIDM00901	Endometrial Carcinoma	GDSC	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation rewiring degron network	0.1944
p.H362N	ACH-000940	Endometrial/Uterine Cancer	CCLE	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation rewiring degron network	0.1944
p.H362N	AN3-CA	endometrium	COSMIC	LRTPGNS	DEG_SCF_FBW7_1	367:373	Mutation rewiring degron network	0.1944
p.M815I	ACH-000278	Ovarian Cancer	CCLE	MNPFPD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.6507
p.S479R	ACH-001282	Bone Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPB41L4B

UniProt ID: Q9H329

Entrez ID: 54566

Protein name: Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPB41L4B in