DegronMD

Uniprot ID: Q9H329

Source protein: Band 4.1-like protein 4B

Source gene: EPB41L4B

Class: LIG_APCC_ABBA_1

Location: 815:820

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9984

ASA_SCORE: 78.6667

COIL: 0.9103

CONS_SCORE: 0.2722

DSS_SCORE: 0.4126

HELIX: 0.0275

FCONS_SCORE: 1.0184

RIG_SCORE: 0.7782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V812L	TCGA-05-5425	LUAD	TCGA	MNPFPD	LIG_APCC_ABBA_1	0.25
p.V812L	DO26270	LUAD	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.25
p.P811L	TCGA-AX-A3GB	UCEC	TCGA	MNPFPD	LIG_APCC_ABBA_1	0.2222
p.P811L	DO41121	UCEC	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.2222
p.T821I	TCGA-IH-A3EA	SKCM	TCGA	MNPFPD	LIG_APCC_ABBA_1	0.3056
p.T821I	DO37667	SKCM	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.3056
p.P817L	TCGA-W3-AA1V	SKCM	TCGA	MNPFPD	LIG_APCC_ABBA_1	0.6471
p.P817L	DO51276	SKCM	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.6471
p.P817S	TCGA-W3-AA1V	SKCM	TCGA	MNPFPD	LIG_APCC_ABBA_1	0.6752
p.P817S	DO51276	SKCM	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.6752
p.N816T	DO229010	COCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.5944
p.N816T	DO229016	COCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.5944
p.N816T	DO229003	COCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.5944
p.N816T	DO229005	COCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.5944
p.G825W	DO229268	THCA	ICGC	MNPFPD	LIG_APCC_ABBA_1	0.1944
p.G825E	SIDM00007	Other Solid Cancers	GDSC	MNPFPD	LIG_APCC_ABBA_1	0.1944
p.G825E	ACH-001550	Skin Cancer	CCLE	MNPFPD	LIG_APCC_ABBA_1	0.1944
p.G825E	MCC13	skin	COSMIC	MNPFPD	LIG_APCC_ABBA_1	0.1944
p.Q827P	SIDM00193	Colorectal Carcinoma	GDSC	MNPFPD	LIG_APCC_ABBA_1	0.1389
p.Q827P	SIDM00488	Colorectal Carcinoma	GDSC	MNPFPD	LIG_APCC_ABBA_1	0.1389
p.Q827P	ACH-000991	Colon/Colorectal Cancer	CCLE	MNPFPD	LIG_APCC_ABBA_1	0.1389
p.Q827P	ACH-002345	Colon/Colorectal Cancer	CCLE	MNPFPD	LIG_APCC_ABBA_1	0.1389
p.Q827P	SNU-81	large_intestine	COSMIC	MNPFPD	LIG_APCC_ABBA_1	0.1389
p.Q827P	CaR-1	large_intestine	COSMIC	MNPFPD	LIG_APCC_ABBA_1	0.1389
p.M815I	ACH-000278	Ovarian Cancer	CCLE	MNPFPD	LIG_APCC_ABBA_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H329	Band 4.1-like protein 4B	LIG_APCC_ABBA_1	815:820	MNPFPD	APC,CDC20,FZR1	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons