DegronMD

Uniprot ID: Q9H329

Source protein: Band 4.1-like protein 4B

Source gene: EPB41L4B

Class: DEG_SCF_FBW7_1

Location: 367:373

E3 ligase: FBXW7

DEGRON score: 0.8439

ASA_SCORE: 81.7571

COIL: 0.8723

CONS_SCORE: 0.5435

DSS_SCORE: 0.2832

HELIX: 0.0349

FCONS_SCORE: 0.7291

RIG_SCORE: 0.7038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D379N	TCGA-AA-3510	COAD	TCGA	LRTPGNS	DEG_SCF_FBW7_1	0.1667
p.D379N	DO7783	COAD	ICGC	LRTPGNS	DEG_SCF_FBW7_1	0.1667
p.A363T	TCGA-AJ-A3BH	UCEC	TCGA	LRTPGNS	DEG_SCF_FBW7_1	0.2222
p.A363T	DO41638	UCEC	ICGC	LRTPGNS	DEG_SCF_FBW7_1	0.2222
p.T369M	TCGA-D1-A174	UCEC	TCGA	LRTPGNS	DEG_SCF_FBW7_1	0.8534
p.T369M	DO40900	UCEC	ICGC	LRTPGNS	DEG_SCF_FBW7_1	0.8534
p.G371E	TCGA-D3-A1QA	SKCM	TCGA	LRTPGNS	DEG_SCF_FBW7_1	0.6087
p.G371E	DO47469	SKCM	ICGC	LRTPGNS	DEG_SCF_FBW7_1	0.6087
p.D379Y	TCGA-KQ-A41N	BLCA	TCGA	LRTPGNS	DEG_SCF_FBW7_1	0.1667
p.D379Y	DO223588	BLCA	ICGC	LRTPGNS	DEG_SCF_FBW7_1	0.1667
p.R368W	DO233857	GACA	ICGC	LRTPGNS	DEG_SCF_FBW7_1	0.7523
p.T369K	DO229026	LICA	ICGC	LRTPGNS	DEG_SCF_FBW7_1	0.8417
p.H362N	SIDM00901	Endometrial Carcinoma	GDSC	LRTPGNS	DEG_SCF_FBW7_1	0.1944
p.H362N	ACH-000940	Endometrial/Uterine Cancer	CCLE	LRTPGNS	DEG_SCF_FBW7_1	0.1944
p.H362N	AN3-CA	endometrium	COSMIC	LRTPGNS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H329	Band 4.1-like protein 4B	DEG_SCF_FBW7_1	367:373	LRTPGNS	FBXW7	0.8439	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons