DegronMD - Q9Y2H5(PLEKHA6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R446C	TCGA-A5-A0G2	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.R446C	DO41235	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.R446C	SIDM00458	Acute Myeloid Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.R446C	SIDM00118	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.R452H	TCGA-A5-A0GB	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.0833
p.R452H	DO41434	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.0833
p.V509I	TCGA-AP-A056	UCEC	TCGA	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation altering degron motif	0.5965
p.V509I	DO43971	UCEC	ICGC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation altering degron motif	0.5965
p.V422I	TCGA-CK-4951	COAD	TCGA	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.1389
p.V422I	DO10582	COAD	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.1389
p.V422I	DO49178	PACA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.1389
p.E436K	TCGA-DZ-6133	KIRP	TCGA	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.E436K	TCGA-DZ-6133	KIRP	TCGA	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.3056
p.E436K	DO52645	BOCA	ICGC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.E436K	DO52645	BOCA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.3056
p.E436K	DO20762	KIRP	ICGC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.E436K	DO20762	KIRP	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.3056
p.R517W	TCGA-EY-A1GD	UCEC	TCGA	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.25
p.R517W	DO42129	UCEC	ICGC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.25
p.R517W	SIDM01387	Small Cell Lung Carcinoma	GDSC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.25
p.R445H	TCGA-FI-A2D5	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.2778
p.R445H	TCGA-FI-A2D5	UCEC	TCGA	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.0556
p.R445H	DO41331	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.2778
p.R445H	DO41331	UCEC	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.0556
p.R429W	DO233760	GACA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation altering degron motif	0.8634
p.R445S	DO229029	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.2778
p.R445S	DO229029	LICA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.0556
p.P425Q	DO229034	LICA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.2222
p.P511S	DO229177	LMS	ICGC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation altering degron motif	0.6752
p.M500L	DO228400	MALY	ICGC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.0833
p.D438H	DO229218	THCA	ICGC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.3056
p.D438H	DO229218	THCA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.25
p.S442I	DO229218	THCA	ICGC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation altering degron motif	0.8453
p.R452C	DO229091	UTCA	ICGC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.0833
p.R429Q	SIDM00499	Prostate Carcinoma	GDSC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation altering degron motif	0.7329
p.R429Q	SIDM01619	Endometrial Carcinoma	GDSC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation altering degron motif	0.7329
p.L520V	SIDM01019	Acute Myeloid Leukemia	GDSC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1667
p.L520V	SIDM00280	Gastric Carcinoma	GDSC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1667
p.L520V	SIDM00363	Acute Myeloid Leukemia	GDSC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1667
p.L520V	SIDM01617	Endometrial Carcinoma	GDSC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1667
p.L520V	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1667
p.L520V	ECC10	stomach	COSMIC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1667
p.L520V	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1667
p.H521R	SIDM00579	Neuroblastoma	GDSC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1389
p.H521R	NB(TU)1-10	autonomic ganglia	COSMIC	VPPYPE	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1389
p.G436R	ACH-000196	Breast Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.G436R	ACH-000196	Breast Cancer	CCLE	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.3056
p.G436R	HCC1599	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.G436R	HCC1599	breast	COSMIC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.3056
p.A433P	ACH-000357	Lymphoma	CCLE	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation altering degron motif	0.7503
p.G436V	ACH-000694	Esophageal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.25
p.G436V	ACH-000694	Esophageal Cancer	CCLE	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.3056
p.R437W	ACH-000889	Myeloma	CCLE	AASSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.2778
p.R437W	ACH-000889	Myeloma	CCLE	RQPVYYD	LIG_APCC_ABBAyCdc20_2	429:435	Mutation rewiring degron network	0.2778
p.S448P	ACH-000937	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	439:443	Mutation blocking phosphorylation signal	0.6389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHA6

UniProt ID: Q9Y2H5

Entrez ID: 22874

Protein name: Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHA6 in