DegronMD

Uniprot ID: Q9Y2H5

Source protein: Pleckstrin homology domain-containing family A member 6

Source gene: PLEKHA6

Class: LIG_APCC_ABBAyCdc20_2

Location: 429:435

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9908

ASA_SCORE: 95.8714

COIL: 0.7713

CONS_SCORE: 0.6078

DSS_SCORE: 0.3861

HELIX: 0.1796

FCONS_SCORE: 1.0833

RIG_SCORE: 0.7647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V422I	TCGA-CK-4951	COAD	TCGA	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V422I	DO10582	COAD	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V422I	DO49178	PACA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E436K	TCGA-DZ-6133	KIRP	TCGA	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E436K	DO52645	BOCA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E436K	DO20762	KIRP	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R445H	TCGA-FI-A2D5	UCEC	TCGA	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R445H	DO41331	UCEC	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R429W	DO233760	GACA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R445S	DO229029	LICA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P425Q	DO229034	LICA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D438H	DO229218	THCA	ICGC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.25
p.R429Q	SIDM00499	Prostate Carcinoma	GDSC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R429Q	SIDM01619	Endometrial Carcinoma	GDSC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.7329
p.G436R	ACH-000196	Breast Cancer	CCLE	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G436R	HCC1599	breast	COSMIC	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A433P	ACH-000357	Lymphoma	CCLE	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.7503
p.G436V	ACH-000694	Esophageal Cancer	CCLE	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R437W	ACH-000889	Myeloma	CCLE	RQPVYYD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H5	Pleckstrin homology domain-containing family A member 6	LIG_APCC_ABBAyCdc20_2	429:435	RQPVYYD	APC,CDC20,FZR1	0.9908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons