DegronMD

Uniprot ID: Q9Y2H5

Source protein: Pleckstrin homology domain-containing family A member 6

Source gene: PLEKHA6

Class: LIG_APCC_ABBA_1

Location: 509:514

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9995

ASA_SCORE: 79.35

COIL: 0.8772

CONS_SCORE: 0.6578

DSS_SCORE: 0.4234

HELIX: 0.0857

FCONS_SCORE: 1.116

RIG_SCORE: 0.6936

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V509I	TCGA-AP-A056	UCEC	TCGA	VPPYPE	LIG_APCC_ABBA_1	0.5965
p.V509I	DO43971	UCEC	ICGC	VPPYPE	LIG_APCC_ABBA_1	0.5965
p.R517W	TCGA-EY-A1GD	UCEC	TCGA	VPPYPE	LIG_APCC_ABBA_1	0.25
p.R517W	DO42129	UCEC	ICGC	VPPYPE	LIG_APCC_ABBA_1	0.25
p.R517W	SIDM01387	Small Cell Lung Carcinoma	GDSC	VPPYPE	LIG_APCC_ABBA_1	0.25
p.P511S	DO229177	LMS	ICGC	VPPYPE	LIG_APCC_ABBA_1	0.6752
p.M500L	DO228400	MALY	ICGC	VPPYPE	LIG_APCC_ABBA_1	0.0833
p.L520V	SIDM01019	Acute Myeloid Leukemia	GDSC	VPPYPE	LIG_APCC_ABBA_1	0.1667
p.L520V	SIDM00280	Gastric Carcinoma	GDSC	VPPYPE	LIG_APCC_ABBA_1	0.1667
p.L520V	SIDM00363	Acute Myeloid Leukemia	GDSC	VPPYPE	LIG_APCC_ABBA_1	0.1667
p.L520V	SIDM01617	Endometrial Carcinoma	GDSC	VPPYPE	LIG_APCC_ABBA_1	0.1667
p.L520V	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	VPPYPE	LIG_APCC_ABBA_1	0.1667
p.L520V	ECC10	stomach	COSMIC	VPPYPE	LIG_APCC_ABBA_1	0.1667
p.L520V	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	VPPYPE	LIG_APCC_ABBA_1	0.1667
p.H521R	SIDM00579	Neuroblastoma	GDSC	VPPYPE	LIG_APCC_ABBA_1	0.1389
p.H521R	NB(TU)1-10	autonomic_ganglia	COSMIC	VPPYPE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H5	Pleckstrin homology domain-containing family A member 6	LIG_APCC_ABBA_1	509:514	VPPYPE	APC,CDC20,FZR1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons